• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甲状腺功能减退患者不孕的一个潜在原因。

A hidden cause of infertility in hypothyroid patients.

作者信息

Allam Magdy Mohamed, El-Zawawy Hanaa Tarek, Barakat Sherine Samir, Ahmed Soha Magdy, Saleh Rasha Noureldin M

机构信息

Internal Medicine Department, Endocrinology Unit Alexandria University Student Hospital (AUSH) Alexandria Egypt.

Internal Medicine Department Faculty of Medicine Alexandria University Alexandria Egypt.

出版信息

Clin Case Rep. 2020 Jan 14;8(2):374-378. doi: 10.1002/ccr3.2654. eCollection 2020 Feb.

DOI:10.1002/ccr3.2654
PMID:32128192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7044389/
Abstract

Methylene tetrahydrofolate reductase (MTHFR) gene mutations could be the cause of infertility in hypothyroid patients. Hence, it is worthy to screen for MTHFR gene mutations in infertile hypothyroid females and their partners if infertility persists after optimizing thyroid function.

摘要

亚甲基四氢叶酸还原酶（MTHFR）基因突变可能是甲状腺功能减退患者不孕的原因。因此，如果在优化甲状腺功能后仍存在不孕问题，对不孕的甲状腺功能减退女性及其伴侣进行MTHFR基因突变筛查是值得的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b4/7044389/c491d3623061/CCR3-8-374-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b4/7044389/c491d3623061/CCR3-8-374-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b4/7044389/c491d3623061/CCR3-8-374-g001.jpg

相似文献

1
A hidden cause of infertility in hypothyroid patients.甲状腺功能减退患者不孕的一个潜在原因。
Clin Case Rep. 2020 Jan 14;8(2):374-378. doi: 10.1002/ccr3.2654. eCollection 2020 Feb.
2
Relationship between cigarette smoking and hypothyroidism in patients with Hashimoto's thyroiditis.桥本甲状腺炎患者吸烟与甲状腺功能减退之间的关系。
J Endocrinol Invest. 1996 Oct;19(9):607-12. doi: 10.1007/BF03349026.
3
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.一项评估胆钙化醇补充对桥本甲状腺炎自身免疫可能作用的前瞻性研究。
J Assoc Physicians India. 2023 Jan;71(1):1.
4
Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function.桥本甲状腺炎与胰岛素依赖型糖尿病：甲状腺功能异常与正常个体之间的差异。
J Clin Endocrinol Metab. 1998 May;83(5):1548-51. doi: 10.1210/jcem.83.5.4769.
5
L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto's thyroiditis.左旋甲状腺素治疗可使特发性黏液性水肿及甲状腺功能减退患者的甲状腺微粒体抗体和甲状腺球蛋白抗体水平下降，但对甲状腺功能正常的桥本甲状腺炎患者则无此作用。
J Endocrinol Invest. 1986 Aug;9(4):299-305. doi: 10.1007/BF03346932.
6
Inhibition by immunoglobulin G of synthesis of thyroid hormone in thyroid cultures from hypothyroid patients with goitrous Hashimoto's thyroiditis.免疫球蛋白G对患有甲状腺肿性桥本甲状腺炎的甲状腺功能减退患者甲状腺培养物中甲状腺激素合成的抑制作用。
Acta Endocrinol (Copenh). 1990 Nov;123(5):511-8. doi: 10.1530/acta.0.1230511.
7
[The clinical course of Hashimoto's thyroiditis during a 5 year observation period in relation to the change in thyroid function and the titers of the antithyroid antibody].[桥本甲状腺炎在5年观察期内的临床病程与甲状腺功能变化及抗甲状腺抗体滴度的关系]
Nihon Naibunpi Gakkai Zasshi. 1990 Mar 20;66(3):207-17. doi: 10.1507/endocrine1927.66.3_207.
8
Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism.桥本甲状腺炎：TGAb、TPOAb、TRAb 与甲状腺功能减退症的恢复。
Expert Rev Clin Immunol. 2008 Mar;4(2):221-37. doi: 10.1586/1744666X.4.2.221.
9
Effects of thyroid status on thyroid autoimmunity expression in euthyroid and hypothyroid patients with Hashimoto's thyroiditis.甲状腺状态对桥本甲状腺炎甲状腺功能正常及甲状腺功能减退患者甲状腺自身免疫表达的影响。
Clin Endocrinol (Oxf). 1994 Apr;40(4):529-35. doi: 10.1111/j.1365-2265.1994.tb02494.x.
10
Elevation of serum immunoglobulin G in Hashimoto's thyroiditis and decrease after treatment with L-thyroxine in hypothyroid patients.桥本甲状腺炎患者血清免疫球蛋白G升高及甲状腺功能减退患者用左甲状腺素治疗后下降。
Intern Med. 2010;49(4):267-71. doi: 10.2169/internalmedicine.49.2154. Epub 2010 Feb 15.

引用本文的文献

1
Association of methylenetetrahydrofolate reductase () gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis.亚甲基四氢叶酸还原酶（）基因多态性（C677T 和 A1298C）与甲状腺功能障碍的关联：一项荟萃分析和试验序贯分析。
Arch Endocrinol Metab. 2022;66(4):551-581. doi: 10.20945/2359-3997000000471. Epub 2022 Jun 23.
2
Thyroid disease and covid-19 infection: Case series.甲状腺疾病与新冠病毒感染：病例系列
Clin Case Rep. 2021 Jun 17;9(6):e04225. doi: 10.1002/ccr3.4225. eCollection 2021 Jun.
3
MTHFR 1298A>C Substitution is a Strong Candidate for Analysis in Recurrent Pregnancy Loss: Evidence from 14,289 Subjects.

本文引用的文献

1
Ethnogeographic prevalence and implications of the 677C>T and 1298A>C polymorphisms in US primary care populations.美国初级保健人群中 677C>T 和 1298A>C 多态性的种族地理流行率及其意义。
Biomark Med. 2019 Jun;13(8):649-661. doi: 10.2217/bmm-2018-0392. Epub 2019 Jun 3.
2
Induction of remission in autoimmune polyglandular syndrome type three (APS III): An old drug with new perspectives.三型自身免疫性多腺体综合征（APS III）缓解的诱导：一种具有新前景的老药物。
Clin Case Rep. 2018 Oct 2;6(11):2178-2184. doi: 10.1002/ccr3.1827. eCollection 2018 Nov.
3
Effect of levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism and thyroid autoimmuneity undergoing in vitro fertilization/intracytoplasmic sperm injection: an updated meta-analysis of randomized controlled trials.
亚甲基四氢叶酸还原酶1298A>C替换是复发性流产分析的有力候选因素：来自14289名受试者的证据。
Reprod Sci. 2022 Apr;29(4):1039-1053. doi: 10.1007/s43032-021-00530-5. Epub 2021 Mar 19.
左旋甲状腺素补充治疗对甲状腺自身免疫的亚临床甲状腺功能减退症行体外受精/卵胞浆内单精子注射妇女妊娠结局的影响：一项随机对照试验的更新荟萃分析。
Reprod Biol Endocrinol. 2018 Sep 24;16(1):92. doi: 10.1186/s12958-018-0410-6.
4
MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.MTHFR 同工型携带者。5-MTHF（5-甲基四氢叶酸）与叶酸：妊娠结局的关键：病例系列。
J Assist Reprod Genet. 2018 Aug;35(8):1431-1435. doi: 10.1007/s10815-018-1225-2. Epub 2018 Jun 7.
5
Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women.孕前抗甲状腺过氧化物酶抗体而非促甲状腺激素与不孕女性活产率降低有关。
Fertil Steril. 2017 Oct 25. doi: 10.1016/j.fertnstert.2017.08.026.
6
Role of CYP51 in the Regulation of T3 and FSH-Induced Steroidogenesis in Female Mice.CYP51在雌性小鼠T3和促卵泡激素诱导的类固醇生成调节中的作用
Endocrinology. 2017 Nov 1;158(11):3974-3987. doi: 10.1210/en.2017-00249.
7
Prevalence of the MTHFR C677T Mutation in Fertile and Infertile Women.育龄期及不孕女性中MTHFR基因C677T突变的患病率
Rev Bras Ginecol Obstet. 2017 Dec;39(12):659-662. doi: 10.1055/s-0037-1606289. Epub 2017 Aug 28.
8
Diet and fertility: a review.饮食与生育：综述。
Am J Obstet Gynecol. 2018 Apr;218(4):379-389. doi: 10.1016/j.ajog.2017.08.010. Epub 2017 Aug 24.
9
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum.美国甲状腺协会2017年妊娠期及产后甲状腺疾病诊断和管理指南。
Thyroid. 2017 Mar;27(3):315-389. doi: 10.1089/thy.2016.0457.
10
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.MTHFR 基因多态性影响胚胎活力和非整倍体发生率。
Hum Genet. 2016 May;135(5):555-568. doi: 10.1007/s00439-016-1652-z. Epub 2016 Apr 11.