Yanai Machi, Ariyoshi Koichi
Department of Emergency Medicine, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Case Rep Emerg Med. 2020 Feb 17;2020:6590101. doi: 10.1155/2020/6590101. eCollection 2020.
Kounis syndrome is a form of acute coronary syndrome caused by allergic reactions. No cases of cardiac arrest caused by Kounis syndrome that arose after the administration of sugammadex have been reported. A 71-year-old female suffered two cardiac arrests. The first occurred after sugammadex was administered at the end of an operation for a right radial distal fracture. The patient was resuscitated and transferred to our intensive care unit. She was subsequently discharged home. Five months later, she suffered a second cardiac arrest after sugammadex was administered at the end of an operation for a right femoral neck fracture at our hospital. Urgent coronary angiography revealed multiple coronary spasms. Kounis syndrome was diagnosed based on the patient's elevated serum trypsin levels and a positive result in a skin allergy test of sugammadex. In cases of cardiac arrest with unclear etiologies, Kounis syndrome should be considered.
库尼斯综合征是一种由过敏反应引起的急性冠状动脉综合征。尚无关于使用舒更葡糖钠后发生库尼斯综合征导致心脏骤停的病例报告。一名71岁女性发生了两次心脏骤停。第一次发生在右桡骨远端骨折手术后使用舒更葡糖钠结束时。患者经复苏后被转入我们的重症监护病房。随后她出院回家。五个月后，在我院进行右股骨颈骨折手术后使用舒更葡糖钠结束时，她再次发生心脏骤停。紧急冠状动脉造影显示多处冠状动脉痉挛。根据患者血清胰蛋白酶水平升高以及舒更葡糖钠皮肤过敏试验阳性结果，诊断为库尼斯综合征。对于病因不明的心脏骤停病例，应考虑库尼斯综合征。
