干细胞移植受者中神经氨酸酶敏感性降低的乙型流感病毒的检测与特征分析
Detection and Characterization of Influenza B Virus With Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient.
作者信息
Kodiyanplakkal Rosy Priya L, Laplante Jennifer M, Westblade Lars F, van Besien Koen, Salvatore Mirella, St George Kirsten
机构信息
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
出版信息
Open Forum Infect Dis. 2019 Nov 18;6(12):ofz493. doi: 10.1093/ofid/ofz493. eCollection 2019 Dec.
Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.
临床环境中抗病毒耐药的流感病毒，尤其是B型流感病毒，鲜有报道。一名干细胞移植受者尽管反复接受抗病毒治疗，但2个月内流感B病毒检测一直呈阳性。实验室检测显示，存在一种对神经氨酸酶抑制剂耐药的流感B病毒，其119位密码子发生了替换，并不断演变且持续存在。
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