School of Software Engineering, South China University of Technology, Guangzhou, P. R. China.
Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Laboratory of Digital Orthopedic Engineering, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, P. R. China.
J Gerontol A Biol Sci Med Sci. 2020 Apr 17;75(5):858-866. doi: 10.1093/gerona/glaa055.
Calorie restriction (CR) has a positive impact on health and life span. Previous work, however, does not reveal the whole underlying mechanism of behavioral phenotypes under CR. We propose a new approach based on phase space reconstruction (PSR) to analyze the behavioral responses of mice to graded CR. This involved reconstructing high-dimensional attractors which topologically represent the intrinsic dynamics of mice based on low-dimensional time series of movement counts observed during the 90-day time course of restriction. PSR together with correlation dimensions (CD), Kolmogorov entropy (KE), and multifractal spectra builds a map from internal attractors to the phenotype of mice and reveals the mice with increasing CR levels undergo significant changes from a normal to a new state. Features of the attractors (CD and KE) were significantly associated with gene expression profiles in the hypothalamus of the same individuals.
热量限制（CR）对健康和寿命有积极影响。然而，以前的工作并没有揭示 CR 下行为表型的全部潜在机制。我们提出了一种基于相空间重建（PSR）的新方法来分析小鼠对分级 CR 的行为反应。这涉及到基于在限制的 90 天时间过程中观察到的低维运动计数时间序列，重建拓扑上表示小鼠内在动力学的高维吸引子。PSR 与关联维数（CD）、柯尔莫哥洛夫熵（KE）和多重分形谱一起，从内部吸引子到小鼠的表型建立了一个图谱，并揭示了随着 CR 水平的增加，小鼠从正常状态到新状态经历了显著的变化。吸引子的特征（CD 和 KE）与同一个体下丘脑的基因表达谱显著相关。
