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马和斑马:一种非典型临床表现,包括吉兰-巴雷综合征、复发性发热和肠系膜淋巴结病,由两种同时发生的感染引起。

A horse and a zebra: an atypical clinical picture including Guillain-Barré syndrome, recurrent fever and mesenteric lymphadenopathy caused by two concomitant infections.

机构信息

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.

Department of Neurology, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

出版信息

Infection. 2020 Jun;48(3):471-475. doi: 10.1007/s15010-020-01397-5. Epub 2020 Mar 3.

Abstract

BACKGROUND

While Campylobacter jejuni represents the most common cause of bacterial gastroenteritis, Yersinia pseudotuberculosis infections are very rarely diagnosed in adults.

CASE

We report on a previously healthy patient who presented several times at our hospital with fever, Guillain-Barré syndrome, recurrent abdominal symptoms and distinct mesenteric lymphadenopathy, respectively. This complicated and diagnostically challenging course of disease was caused by a C. jejuni and Y. pseudotuberculosis coinfection. Antibiotic treatment with doxycycline was effective.

CONCLUSION

Broad serology testing was crucial to discover that two concomitant infections were causing the symptoms. This case demonstrates that when a clinical picture is not fully explained by one known infection, another infection with the same underlying risk factor has to be considered, hence "a horse and a zebra".

摘要

背景

虽然空肠弯曲菌是细菌性胃肠炎最常见的原因,但在成人中,很少诊断出假结核耶尔森菌感染。

病例报告

我们报告了一例既往健康的患者,他因发热、格林-巴利综合征、反复腹痛和明显肠系膜淋巴结病分别多次在我院就诊。这种复杂且具有挑战性的疾病过程是由空肠弯曲菌和假结核耶尔森菌合并感染引起的。多西环素的抗生素治疗是有效的。

结论

广泛的血清学检测对于发现两种同时存在的感染是导致这些症状的关键。该病例表明,当一种临床症状不能完全由一种已知的感染来解释时,必须考虑到另一种具有相同潜在危险因素的感染,因此称之为“既有马,又有斑马”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250e/7256024/83be42cd9503/15010_2020_1397_Fig1_HTML.jpg

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