铜（II）催化芳胺的邻位C（sp）-H二芳基胺化反应合成三芳基胺
Cu(II)-Catalyzed Ortho C(sp)-H Diarylamination of Arylamines To Synthesize Triarylamines.
作者信息
Kumar Mohit, Sharma Rishabh, Khan Afsar Ali, Ahmad Ashfaq, Dutta Himangsu Sekhar, Koley Dipankar
机构信息
Academy of Scientific and Innovative Research, New Delhi, 110001, India.
National Institute of Pharmaceutical Education and Research, Chunilal Bhawan, 168, Manicktala Road, Kolkata, 700054, India.
出版信息
Org Lett. 2020 Mar 20;22(6):2152-2156. doi: 10.1021/acs.orglett.0c00196. Epub 2020 Mar 4.
A copper-catalyzed, directed C-H diarylamination of indoles, indolines, anilines, and -aryl-7-azaindoles has been established. Only copper salt as the catalyst and oxygen as the terminal oxidant are used to synthesize triarylamines using various diarylamines including carbazole and phenothiazine. Mechanistic interrogation reveals that copper plays a dual role.
已实现铜催化的吲哚、二氢吲哚、苯胺和β-芳基-7-氮杂吲哚的定向C-H二芳基胺化反应。仅使用铜盐作为催化剂，以氧气作为终端氧化剂，利用包括咔唑和吩噻嗪在内的各种二芳基胺来合成三芳基胺。机理研究表明，铜起着双重作用。
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