Department of Obstetrics and Gynecology and Pediatrics, University of Modena and Reggio Emilia, Modena, Italy.
Oncological Endocrinology Unit, Regina Elena National Cancer Institute - IRCCS, Rome, Italy.
Expert Opin Drug Metab Toxicol. 2020 Mar;16(3):255-274. doi: 10.1080/17425255.2020.1737675. Epub 2020 Mar 19.
: This Experts' opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM).: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients.: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients.
这一专家意见为妇科医生、产科医生、内分泌学家、营养师、神经学家和全科医生提供了关于肌醇（MI）和 D-手性肌醇（DCI）在多囊卵巢综合征（PCOS）和非胰岛素依赖型（2 型）糖尿病（NIDDM）治疗中的应用的最新科学依据。本文总结了 MI 和 DCI 的生理学，这两种物质是人体中两种重要的分子，具有治疗作用，也可用于治疗不孕。还讨论了 MI 和 DCI 之间在生理功能上的一些深刻差异，以及它们的安全性和肠道吸收。更新内容包括关于 MI/DCI 比例为 40:1 在 PCOS 中发挥的疗效的新证据，以及基于α-乳白蛋白的创新方法，以克服某些患者中肌醇治疗效果降低的问题。有证据表明，MI 单独使用或与 40:1 比例的 DCI 联合使用，为 PCOS 和 NIDDM 提供了一种有前途的治疗方法。然而，仍需要进一步研究来评估一些尚未解决的问题，例如治疗 NIDDM 的最佳 MI/DCI 比例、由于 MI 治疗而减少 IVF 中促性腺激素给药的潜在成本效益，或在 PCOS 患者中使用枸橼酸氯米酚诱导排卵时补充 MI 的益处。
