Department of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6, 44-100 Gliwice, Poland.
Department of Plant Physiology, Genetics and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A/103A, 10-719 Olsztyn, Poland.
Molecules. 2021 Dec 28;27(1):158. doi: 10.3390/molecules27010158.
The conditions for determining the antioxidant properties of cyclitols (d-pinitol, l-quebrachitol, -, l--, and d--inositol), selected flavanones (hesperetin, naringenin, eriodictyol, and liquiritigenin) and glutathione by spectrophotometric methods-CUPRAC and with DPPH radical, and by a chromatographic method DPPH-UHPLC-UV, have been identified. Interactions of the tested compounds and their impact on the ox-red properties were investigated. The RSA (%) of the compounds tested was determined. Very low antioxidative properties of cyclitols, compared with flavanones and glutathione alone, were revealed. However, a significant increase in the determined antioxidative properties of glutathione by methyl-ether derivatives of cyclitols (d-pinitol and l-quebrachitol) was demonstrated for the first time. Thus, cyclitols seem to be a good candidate for creating drugs for the treatment of many diseases associated with reactive oxygen species (ROS) generation.
已经确定了通过分光光度法（CUPRAC 和 DPPH 自由基）和色谱法（DPPH-UHPLC-UV）测定环糖醇（D-松醇、L-奎诺醇、埃罗迪西醇和 D-肌醇）、几种黄烷酮（橙皮素、柚皮素、圣草酚和甘草素）和谷胱甘肽抗氧化性能的条件。研究了测试化合物的相互作用及其对氧化还原性质的影响。测定了化合物的 RSA（%）。与黄烷酮和谷胱甘肽单独相比，环糖醇的抗氧化性能非常低。然而，首次证明了环糖醇的甲基醚衍生物（D-松醇和 L-奎诺醇）可显著提高谷胱甘肽的抗氧化性能。因此，环糖醇似乎是一种很有前途的候选药物，可以用于治疗许多与活性氧（ROS）生成相关的疾病。
