分析选定环糖醇及其与黄烷酮和谷胱甘肽混合物的抗氧化性能。

Analyses of Antioxidative Properties of Selected Cyclitols and Their Mixtures with Flavanones and Glutathione.

机构信息

Department of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Faculty of Chemistry, Silesian University of Technology, B. Krzywoustego 6, 44-100 Gliwice, Poland.

Department of Plant Physiology, Genetics and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A/103A, 10-719 Olsztyn, Poland.

出版信息

Molecules. 2021 Dec 28;27(1):158. doi: 10.3390/molecules27010158.

DOI:10.3390/molecules27010158

PMID:35011390

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8746988/

Abstract

The conditions for determining the antioxidant properties of cyclitols (d-pinitol, l-quebrachitol, -, l--, and d--inositol), selected flavanones (hesperetin, naringenin, eriodictyol, and liquiritigenin) and glutathione by spectrophotometric methods-CUPRAC and with DPPH radical, and by a chromatographic method DPPH-UHPLC-UV, have been identified. Interactions of the tested compounds and their impact on the ox-red properties were investigated. The RSA (%) of the compounds tested was determined. Very low antioxidative properties of cyclitols, compared with flavanones and glutathione alone, were revealed. However, a significant increase in the determined antioxidative properties of glutathione by methyl-ether derivatives of cyclitols (d-pinitol and l-quebrachitol) was demonstrated for the first time. Thus, cyclitols seem to be a good candidate for creating drugs for the treatment of many diseases associated with reactive oxygen species (ROS) generation.

摘要

已经确定了通过分光光度法（CUPRAC 和 DPPH 自由基）和色谱法（DPPH-UHPLC-UV）测定环糖醇（D-松醇、L-奎诺醇、埃罗迪西醇和 D-肌醇）、几种黄烷酮（橙皮素、柚皮素、圣草酚和甘草素）和谷胱甘肽抗氧化性能的条件。研究了测试化合物的相互作用及其对氧化还原性质的影响。测定了化合物的 RSA（%）。与黄烷酮和谷胱甘肽单独相比，环糖醇的抗氧化性能非常低。然而，首次证明了环糖醇的甲基醚衍生物（D-松醇和 L-奎诺醇）可显著提高谷胱甘肽的抗氧化性能。因此，环糖醇似乎是一种很有前途的候选药物，可以用于治疗许多与活性氧（ROS）生成相关的疾病。