异吲哚酮对实验宿主细粒棘球绦虫囊肿的影响。

The effect of isatin on the Echinococcus granulosus cyst in an experimental host.

作者信息

Piens M A, Sarciron E, Audin P, Mojon M, Petavy A F, Gabrion C

机构信息

Departement de Parasitologie et Pathologie Exotique, Université Claude Bernard, Lyon, France.

出版信息

Vet Parasitol. 1988 Nov;30(1):31-44. doi: 10.1016/0304-4017(88)90140-9.

DOI:10.1016/0304-4017(88)90140-9

PMID:3212928

Abstract

The effect of isatin on the E. granulosus cyst was studied. NMRI mice, which were infected with E. granulosus of sheep origin, were treated daily with isatin at a dose of 50 mg kg-1 for 18 days. Ultrastructural damage was observed in the treated cysts, including accumulation of lamellar stacks, electron-dense granules, autophagosomes and lipid vesicles. Moreover, a biochemical study showed an inhibition of alkaline phosphatase activity, with a decrease in carbohydrate storage and an increase in acid phosphatase activity. In spite of the short duration of the treatment, the results obtained allowed us to conclude that isatin acts on E. granulosus cysts. This activity appears as a process of degeneration linked to the alkaline phosphatase inhibitory effect of isatin.

摘要

研究了异吲哚酮对细粒棘球绦虫囊肿的影响。用源自绵羊的细粒棘球绦虫感染的NMRI小鼠，每天以50mg/kg的剂量给予异吲哚酮，持续18天。在处理过的囊肿中观察到超微结构损伤，包括板层堆积、电子致密颗粒、自噬体和脂质小泡的积累。此外，生化研究表明碱性磷酸酶活性受到抑制，碳水化合物储存减少，酸性磷酸酶活性增加。尽管治疗时间较短，但获得的结果使我们能够得出结论，异吲哚酮作用于细粒棘球绦虫囊肿。这种活性表现为与异吲哚酮的碱性磷酸酶抑制作用相关的退化过程。