Sarciron M E, Walbaum S, Petavy A F
Department of Parasitology and Medical Mycology, Claude-Bernard University, Lyon, France.
Parasitol Res. 1995;81(4):329-33. doi: 10.1007/BF00931540.
An in vivo study of the effect of Isoprinosine on Echinococcus multilocularis and E. granulosus metacestodes (Cestoda) was performed. Short- and long-term treatments with different doses were tested in experimental hosts: jirds for E. multilocularis and mice for E. granulosus. Modifications in the weight of animals as well as macroscopical and ultrastructural aspects were registered for each animal group. The results obtained showed a considerable ultrastructural alteration in E. multilocularis metacestodes after short-term treatment with the highest dose, and the tissue transplants were negative. In E. granulosus cysts the ultrastructural damage was also very important and its severity increased as the dose was raised. For the two parasites, the macroscopical aspect and weight of the lesions were profoundly changed.
进行了一项关于异丙肌苷对多房棘球绦虫和细粒棘球绦虫中绦期幼虫（绦虫纲）影响的体内研究。在实验宿主中测试了不同剂量的短期和长期治疗：用长爪沙鼠作为多房棘球绦虫的宿主，用小鼠作为细粒棘球绦虫的宿主。记录了每个动物组动物体重的变化以及宏观和超微结构方面的情况。获得的结果表明，用最高剂量进行短期治疗后，多房棘球绦虫中绦期幼虫出现了相当大的超微结构改变，并且组织移植呈阴性。在细粒棘球绦虫囊肿中，超微结构损伤也非常严重，并且随着剂量增加其严重程度也增加。对于这两种寄生虫，病变的宏观外观和重量都发生了深刻变化。
