基于比率的 FMR 方法用于使用响应性顺磁探针定量 Ca。
A ratiometric F MR-based method for the quantification of Ca using responsive paramagnetic probes.
机构信息
MR Neuroimaging Agents, MPI for Biological Cybernetics, Tuebingen, Germany.
出版信息
Chem Commun (Camb). 2020 Mar 25;56(24):3492-3495. doi: 10.1039/c9cc09977h. Epub 2020 Mar 4.
PMID:32129333
Abstract
We present a method for assessing the extracellular calcium concentration using F chemical shift imaging. Specifically, a custom made calcium-responsive and lanthanide-based F MRI probe that undergoes a strong and highly specific modulation of its signal upon coordination with calcium ions was developed and its performance is presented.
摘要
我们提出了一种使用 F 化学位移成像评估细胞外钙离子浓度的方法。具体来说，我们开发了一种定制的钙响应和镧系元素基 F MRI 探针，当与钙离子配位时，其信号会发生强烈且高度特异的调制，并展示了其性能。
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