NF-κB c-Rel 在健康和疾病中对 B 细胞功能的调节。
Regulation of B-cell function by NF-kappaB c-Rel in health and disease.
机构信息
Department of Pathology, School of Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, 6526, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA.
Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
出版信息
Cell Mol Life Sci. 2020 Sep;77(17):3325-3340. doi: 10.1007/s00018-020-03488-w. Epub 2020 Mar 4.
Abstract
B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-κB) family of transcription factors play a major role in regulating B-cell functions. NF-κB subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.
摘要
B 细胞介导体液免疫应答，并有助于调节细胞免疫应答。核因子 kappaB（NF-κB）转录因子家族的成员在调节 B 细胞功能方面发挥着重要作用。NF-κB 亚基 c-Rel 主要在淋巴细胞中表达，在 B 细胞中，它是细胞存活、增殖和抗体产生所必需的。c-Rel 的表达和激活失调会改变 B 细胞的内稳态，并与 B 细胞淋巴瘤和自身免疫性疾病有关。基于其重要作用，c-Rel 可能成为一个有潜力的预后和治疗靶点。本综述总结了目前对 c-Rel 在 B 细胞和 B 细胞疾病中的多方面作用的理解。
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