Mingazov E R, Pavlova E N, Surkov S A, Ugrumov M V
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
National Research University Higher School of Economics, 101000, Moscow, Russia.
Dokl Biochem Biophys. 2019 Nov;489(1):399-402. doi: 10.1134/S1607672919060115. Epub 2020 Mar 4.
Nigrostriatal dopaminergic neurons (DNs), involved in the regulation of motor function, are characterized by a high plasticity. Indeed, at the death of up to 50% of DNs in Parkinson's disease, the survived neurons provide normal regulation. This study was aimed to determine whether the vesicle cycle proteins, syntaxin Ia (Syn Ia), synaptotagmin I (Syt I), Rab5a, and complexins I and II (Cmpx I and II) are involved in the mechanisms of neuroplasticity in the substantia nigra, which mainly contains cell bodies and processes of the DNs. In the neurotoxic models of Parkinson's disease in mice, it was shown that, at the degeneration of up to 50% of DNs, the content of Syt I, Syn Ia, and Cmpх I and II, involved in vesicle exocytosis, does not change in the substantia nigra as a whole but is compensatorily increased in individual survived DNs. Thus, the data obtained in this study suggest that the impairment of motor behavior, which occurs at the death of half of the nigrostriatal DNs, is not caused by the impairment of the production of vesicle cycle proteins in the survived DNs.
黑质纹状体多巴胺能神经元（DNs）参与运动功能的调节，其特点是具有高度可塑性。事实上，在帕金森病中多达50%的DNs死亡时，存活的神经元仍能提供正常调节。本研究旨在确定囊泡循环蛋白，即 syntaxin Ia（Syn Ia）、突触结合蛋白I（Syt I）、Rab5a以及复合体蛋白I和II（Cmpx I和II）是否参与黑质神经可塑性机制，黑质主要包含DNs的细胞体和突起。在小鼠帕金森病神经毒性模型中，研究表明，在多达50%的DNs发生变性时，参与囊泡胞吐作用的Syt I、Syn Ia以及Cmpx I和II的含量在整个黑质中并未改变，但在单个存活的DNs中会出现代偿性增加。因此，本研究获得的数据表明，在黑质纹状体DNs半数死亡时出现的运动行为损伤并非由存活DNs中囊泡循环蛋白产生受损所致。
