Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Adv Exp Med Biol. 2020;1219:259-293. doi: 10.1007/978-3-030-34025-4_14.
The human body requires a constant delivery of fresh blood cells that are needed to maintain body homeostasis. Hematopoiesis is the process that drives the formation of new blood cells from a single stem cell. This is a complex, orchestrated and tightly regulated process that occurs within the bone marrow. When such process is faulty or deregulated, leukemia arises, develops and thrives by subverting normal hematopoiesis and availing the supplies of this rich milieu.In this book chapter we will describe and characterize the bone marrow microenvironment and its key importance for leukemia expansion. The several components of the bone marrow niche, their interaction with the leukemic cells and the cellular pathways activated within the malignant cells will be emphasized. Finally, novel therapeutic strategies to target this sibling interaction will also be discussed.
人体需要不断输送新鲜的血细胞，以维持体内平衡。造血是指从单个干细胞中生成新血细胞的过程。这个过程非常复杂，需要精心协调和严格调控，发生在骨髓中。当这个过程出现故障或失调时，白血病就会产生、发展和茁壮成长，它会颠覆正常的造血过程，并利用这个丰富的环境中的资源。在本章中，我们将描述和表征骨髓微环境及其对白血病扩展的关键重要性。强调骨髓龛的几个组成部分、它们与白血病细胞的相互作用以及恶性细胞内激活的细胞通路。最后，还将讨论针对这种细胞间相互作用的新治疗策略。
