Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia Stem Cell Initiative, Columbia University Medical Center, 630 West 168th ST, P&S 7-513, New York, 10032, New York, USA.
Bioessays. 2018 Mar;40(3). doi: 10.1002/bies.201700190. Epub 2018 Jan 31.
Various cell types cooperate to create a highly organized and dynamic micro-environmental niche in the bone marrow. Over the past several years, the field has increasingly recognized the critical roles of the interplay between bone marrow environment and hematopoietic cells in normal and deranged hematopoiesis. These advances rely on several new technologies that have allowed us to characterize the identity and roles of these niches in great detail. Here, we review the progress of the last several years, list some of the outstanding questions in the field and propose ways to target the diseased environment to better treat hematologic diseases. Understanding the extrinsic regulation by the niche will help boost hematopoiesis for regenerative medicine. Based on natural development of hematologic malignancies, we propose that combinatory targeting the niche and hematopoietic intrinsic mechanisms in early stages of hematopoietic malignancies may help eliminate minimal residual disease and have the highest efficacy.
各种细胞类型共同协作，在骨髓中创造出一个高度组织化和动态的微环境龛。在过去的几年中，该领域越来越认识到骨髓环境与造血细胞之间相互作用在正常和失调造血中的关键作用。这些进展依赖于几项新技术，这些技术使我们能够非常详细地描述这些龛的特征和作用。在这里，我们回顾了过去几年的进展，列出了该领域的一些悬而未决的问题，并提出了靶向病变环境以更好地治疗血液疾病的方法。了解龛的外在调节将有助于促进再生医学中的造血。基于血液恶性肿瘤的自然发展，我们提出在血液恶性肿瘤的早期阶段联合靶向龛和造血内在机制可能有助于消除微小残留疾病并获得最高疗效。
