Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, Canada.
Can J Public Health. 2020 Oct;111(5):743-751. doi: 10.17269/s41997-020-00297-3. Epub 2020 Mar 4.
The inflammatory biomarker C-reactive protein (CRP) measures systemic inflammation and has been shown to be increased in patients with mood disorders such as depression. The objective of this study was to determine the association between self-reported mood disorders with CRP levels in a representative sample of the Canadian population using the Canadian Health Measures Survey (CHMS) data 2013-2014.
The CHMS is an ongoing national cross-sectional survey of Canadians about their general health. The current study used the data collected from Cycle 3 (2012/13) and was limited to adults aged 18 and older. Survey weights were assigned to adjust for non-response and non-random sample selection of the responding sample.
Data were analyzed from 5782 respondents (400 (6.9%) self-reported mood disorders and 5382 (93.1%) reported no mood disorders). The CRP level was significantly higher among those with mood disorders than among those without (3.22 (0.17) vs. 2.34 (0.04) mg/L, p = 0.003). Respondents with CRP levels > 10.00 mg/L had 2.69 greater odds of reporting a mood disorder compared with those with CRP levels ≤ 1.00 mg/L (p = 0.02). Higher proportions of respondents with mood disorders were older, had lower BMI, had secondary education, had weak sense of community, had higher proportion of asthma or arthritis, were current/past smokers, had daily consumption of 3+ drinks of alcohol, and used prescription drugs, cannabis/hashish, or other drugs compared with those without mood disorders (all p's < 0.05).
This study supported the association of CRP and mood disorder, specifically in a representative sample of the Canadian population. Targeting inflammation in depression and mood disorder warrants further study.
炎症生物标志物 C 反应蛋白（CRP）可衡量全身炎症水平，且已有研究表明，抑郁症等情绪障碍患者的 CRP 水平会升高。本研究旨在使用 2013-2014 年加拿大健康测量调查（CHMS）的数据，确定加拿大代表性人群中自我报告的情绪障碍与 CRP 水平之间的关联。
CHMS 是一项针对加拿大民众整体健康状况的全国性横断面调查。本研究使用了来自第 3 轮（2012/13 年）的数据，仅限于 18 岁及以上的成年人。调查权重的赋值旨在调整无应答和响应样本选择的非随机抽样的影响。
共分析了 5782 名受访者的数据（400 名（6.9%）自我报告有情绪障碍，5382 名（93.1%）报告无情绪障碍）。与无情绪障碍者相比，有情绪障碍者的 CRP 水平显著更高（3.22（0.17）vs. 2.34（0.04）mg/L，p=0.003）。CRP 水平＞10.00mg/L 的受访者报告情绪障碍的可能性是 CRP 水平≤1.00mg/L 者的 2.69 倍（p=0.02）。有情绪障碍者更可能年龄较大、BMI 较低、接受过中等教育、社区归属感较弱、哮喘或关节炎比例较高、是当前/过去吸烟者、每日饮用 3 杯或以上酒精饮料、使用处方药物、大麻/哈希什或其他药物，而无情绪障碍者则不然（所有 p 值均＜0.05）。
本研究支持 CRP 与情绪障碍之间的关联，特别是在加拿大代表性人群中。针对抑郁症和情绪障碍的炎症靶向治疗值得进一步研究。
