Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain. Electronic address: https://twitter.com/HamczykMagda.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
J Am Coll Cardiol. 2020 Mar 3;75(8):919-930. doi: 10.1016/j.jacc.2019.11.062.
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.
衰老是血管疾病以及随之而来的心血管和脑血管事件的主要风险因素，这些疾病是全球死亡的主要原因。在人口日益老龄化的情况下，开发能够有效识别那些有加速血管损伤风险的个体的早期生命生物标志物至关重要，其最终目标是改善一级预防，并降低与年龄相关的心血管疾病对医疗保健和社会经济的影响。在实验模型和人类中的研究已经确定了 9 个高度相互关联的标志性过程，这些过程驱动着哺乳动物的衰老。然而，延长健康寿命和寿命的策略需要了解个体之间与年龄相关的功能下降的差异，即生物衰老。这篇综述总结了目前关于生物年龄生物标志物、影响生物衰老的因素以及抗衰老干预措施的知识，重点关注衰老过程中的血管方面及其与心血管疾病相关的表现。
