Tian Yuan, Lu Qiao, Li Jing, Zhou Xiaobo, Wang Luyao, Zhong Xuemei, Luo Yiping
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.
Front Aging. 2025 Jul 8;6:1516664. doi: 10.3389/fragi.2025.1516664. eCollection 2025.
Depressive mood may influence biological aging and the difference (δ-age) between biological age (BA) and chronological age (CA). This study explores the relationship between depressive mood and whole-body delta age (δ-age).
A total of 7,383 U.S. adults were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Depressed mood was evaluated using PHQ-9 scores. Biological age (BA) was estimated based on circulating biomarkers, and the calculated delta age (δ-age) was validated through a generalized linear regression analysis.
After adjusting for confounding variables, logistic regression analysis demonstrated a significant association between elevated depressive symptoms and accelerated biological aging. The restricted cubic splines (RCS) results further indicated a positive dose-response relationship between depression scale scores and the risk of biological aging. Additionally, the weighted quantile sum regression (WQS) findings revealed a positive, though non-significant, trend linking depressive mood to the risk of biological aging. Notably, overeating and low self-perception emerged as the most significant contributors to the scores on the Patient Health Questionnaire-9 (PHQ-9) scale.
Depressive symptoms are linked to accelerated biological aging. Thus, interventions aimed at improving mood may help slow biological aging and contribute to delaying the aging process.
抑郁情绪可能会影响生物衰老以及生物年龄（BA）与实际年龄（CA）之间的差异（δ年龄）。本研究探讨了抑郁情绪与全身δ年龄之间的关系。
从2007年至2018年进行的美国国家健康与营养检查调查（NHANES）中选取了7383名美国成年人。使用PHQ-9评分评估抑郁情绪。基于循环生物标志物估计生物年龄（BA），并通过广义线性回归分析验证计算出的δ年龄（δ年龄）。
在调整混杂变量后，逻辑回归分析表明抑郁症状加重与生物衰老加速之间存在显著关联。受限立方样条（RCS）结果进一步表明抑郁量表评分与生物衰老风险之间存在正剂量反应关系。此外，加权分位数和回归（WQS）结果显示抑郁情绪与生物衰老风险之间存在正相关趋势，尽管不显著。值得注意的是，暴饮暴食和自我认知低是患者健康问卷-9（PHQ-9）量表得分的最重要因素。
抑郁症状与生物衰老加速有关。因此，旨在改善情绪的干预措施可能有助于减缓生物衰老并有助于延缓衰老过程。
