Department of Pathology, University of Chicago Medicine, Chicago, IL.
Department of Pathology, University of Chicago Medicine, Chicago, IL.
Semin Nephrol. 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008.
As early detection and advances in the treatment for renal cell carcinoma continue to lead to excellent oncologic outcomes, the preservation of renal function in kidney cancer patients has emerged as an increasingly important clinical objective. Given that diabetes, hypertension, obesity, cigarette smoking, and aging are independent risk factors for renal cell carcinoma, the corresponding non-neoplastic kidney diseases frequently are present, but often undiagnosed. In addition, the subsequent clinical management of the ensuing chronic kidney disease historically has not included nephrologists. Awareness of these practice gaps remain low among nephrologists, surgeons, and pathologists. This article discusses the common non-neoplastic kidney diseases that are encountered in cancer nephrectomy specimens. The accurate and timely diagnosis of these disorders will result in additional gains in clinical outcomes. There is a unique opportunity for the nephrology community to play a central role in the management of chronic kidney disease that often is present in kidney cancer patients.
随着肾癌的早期检测和治疗进展不断带来出色的肿瘤学结果，保护肾癌患者的肾功能已成为一个日益重要的临床目标。鉴于糖尿病、高血压、肥胖、吸烟和衰老都是肾癌的独立危险因素，相应的非肿瘤性肾脏疾病经常存在，但往往未被诊断。此外，随后对慢性肾脏病的临床管理传统上并不包括肾病学家。肾病学家、外科医生和病理学家对这些实践差距的认识仍然很低。本文讨论了在肾癌肾切除标本中常见的非肿瘤性肾脏疾病。准确和及时地诊断这些疾病将进一步提高临床结果。肾病学界有机会在经常存在于肾癌患者中的慢性肾脏病的管理中发挥核心作用。
