Beloff-Chain A, Newman M E, Mansford K R
Horm Metab Res. 1977 Jan;9(1):33-7. doi: 10.1055/s-0028-1093579.
The control of insulin and glucagon secretion from isolated pancreatic islets of lean and genetically obese mice has been compared. The enlarged islets of obese mouse pancreas and islets of obese mouse pancreas and islets of obese mice maintained on a restricted diet manifested a greater response to glucose stimulation of insulin secretion than the lean mice islets. The glucagon content of the islets, the secretion of glucagon in a medium containing 150 mg% glucose and the stimulation of glucagon secretion by arginine did not differ significantly in the two groups. Adrenaline stimulated glucagon secretion in vitro from obese mice but not from lean mice. Antinsulin serum injections into obese mice increased the plasma glucagon levels about twofold and had no effect on glucagon levels in lean mice, although the level of hyperglycaemia was the same in both groups. It is suggested that the suppression of glucagon release by glucose requires a higher concentration of insulin in the obese mouse pancreas than in lean mice.
对正常小鼠和遗传性肥胖小鼠分离胰岛中胰岛素和胰高血糖素分泌的控制情况进行了比较。肥胖小鼠胰腺中增大的胰岛以及限食的肥胖小鼠胰腺胰岛对葡萄糖刺激胰岛素分泌的反应比正常小鼠胰岛更大。两组胰岛中胰高血糖素含量、在含150mg%葡萄糖的培养基中胰高血糖素的分泌以及精氨酸对胰高血糖素分泌的刺激均无显著差异。肾上腺素在体外刺激肥胖小鼠而非正常小鼠的胰高血糖素分泌。给肥胖小鼠注射抗胰岛素血清可使血浆胰高血糖素水平升高约两倍，而对正常小鼠的胰高血糖素水平无影响，尽管两组的高血糖水平相同。这表明，与正常小鼠相比，肥胖小鼠胰腺中葡萄糖对胰高血糖素释放的抑制需要更高浓度的胰岛素。
