Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620910645. doi: 10.1177/2324709620910645.
species are gram-positive, facultative anaerobic bacilli. Infection caused by species is usually limited to cervicofacial, thoracic, and abdominopelvic regions. Infective endocarditis due to species is extremely rare with only 30 reported cases since 1939. We report a case of endocarditis in a 14-year-old boy who had a 2-week history of dyspnea on exertion without other constitutional signs. Transthoracic echocardiography was suggestive of perforation of the right coronary cusp of aortic valve. No organisms were isolated from blood cultures. The patient underwent surgical valve repair due to deteriorated cardiac function. Valve tissue culture did not initially identify the organism. However, the terminal subculture in a thioglycolate broth grew gram-positive bacilli. The matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) was compatible with . After 6 weeks of intravenous ampicillin, the patient remained well with improved cardiac function. We reviewed all reported cases of infective endocarditis caused by species, commenting on clinical characteristics and factors associated with unfavorable outcomes in infective endocarditis due to species. Although infective endocarditis caused by spp is rare, it could be considered in a case of culture-negative endocarditis since the clinical features might be indistinguishable from other bacterial endocarditis. Additionally, MALDI-TOF MS is a useful diagnostic tool for the identification of spp to improve the accuracy of diagnosis.
种是革兰阳性、兼性厌氧杆菌。种引起的感染通常局限于头颈部、胸部和腹部盆腔区域。种引起的感染性心内膜炎极为罕见,自 1939 年以来仅报告了 30 例。我们报告了 1 例 14 岁男孩的感染性心内膜炎病例,该男孩有 2 周的劳力性呼吸困难病史,无其他全身症状。经胸超声心动图提示主动脉瓣右冠状动脉瓣穿孔。血培养未分离出病原体。由于心脏功能恶化,患者接受了手术瓣膜修复。瓣膜组织培养最初未鉴定出病原体。然而,在巯基醋酸盐肉汤中的终末亚培养长出革兰阳性杆菌。基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)与 相兼容。静脉注射氨苄西林 6 周后,患者情况良好,心功能改善。我们回顾了所有报告的由种引起的感染性心内膜炎病例,评论了种引起的感染性心内膜炎的临床特征和与不良预后相关的因素。尽管由种引起的感染性心内膜炎罕见,但在培养阴性的心内膜炎中可以考虑这种病原体,因为其临床特征可能与其他细菌性心内膜炎无法区分。此外,MALDI-TOF MS 是一种用于鉴定种的有用诊断工具,可以提高诊断的准确性。