Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey; and.
NJRetina, New Brunswick, New Jersey.
Retin Cases Brief Rep. 2022 May 1;16(3):351-354. doi: 10.1097/ICB.0000000000000979. Epub 2020 Mar 2.
To report the outcomes of topical difluprednate 0.05% use in the closure of full-thickness macular holes.
Retrospective chart review of 4 patients with full-thickness macular holes who received difluprednate drops 4 times daily for a minimum of 12 weeks. Main outcome measures were macular hole status assessed with optical coherence tomography, visual acuity, intraocular pressure, and complications of treatment.
All patients had macular hole closure within 12 weeks of difluprednate exposure. Mean time to macular hole closure was 5 weeks (range, 2-12 weeks). Visual acuity improved with macular hole closure. Average baseline visual acuity was 20/42. Average visual acuity after macular hole closure was 20/26 (P = 0.14). Two patients experienced increased intraocular pressure with topical steroid use.
Exposure to difluprednate in this cohort of patients with full-thickness macular holes was associated with reduced macular edema, macular hole closure, and visual improvement.
报告局部使用二氟泼尼酯 0.05% 治疗全层黄斑裂孔的结果。
回顾性分析 4 例全层黄斑裂孔患者的病历，这些患者每日使用二氟泼尼酯滴眼剂 4 次，持续至少 12 周。主要观察指标为光学相干断层扫描评估的黄斑裂孔状态、视力、眼压和治疗相关并发症。
所有患者在接受二氟泼尼酯治疗 12 周内黄斑裂孔均闭合。黄斑裂孔闭合的平均时间为 5 周（范围：2-12 周）。黄斑裂孔闭合后视力提高。平均基线视力为 20/42。黄斑裂孔闭合后平均视力为 20/26（P = 0.14）。2 例患者在使用局部皮质类固醇后眼压升高。
本队列中接受全层黄斑裂孔治疗的患者暴露于二氟泼尼酯后黄斑水肿减轻、黄斑裂孔闭合、视力改善。
