Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
Sci Rep. 2020 Mar 4;10(1):4006. doi: 10.1038/s41598-020-60979-3.
Hearing loss becomes increasingly common with age and affects quality of life. Recently, scientists have published articles about the relationship between metabolic disease and hearing loss. Metabolic disease was previously found to be highly related to an increase in alkaline phosphatase. Thus, there may be an indirect relationship between alkaline phosphatase (ALP) and hearing loss. In this paper, we will demonstrate the relationship between ALP and hearing loss. We included 3877 National Health and Nutrition Examination Survey (NHANES) participants, who represent the noninstitutionalized civilian population in the United States from age 20 to age 69, and examined the association between ALP and frequency distributions of pure-tone air-condition (PTAC) thresholds. After adjusting for pertinent variables, the subjects who belonged to the higher quartiles of ALP tended to have worse hearing thresholds (pure tone average at high and low frequencies) than the first quartile of ALP (p < 0.001). The results showed a positive correlation between ALP and hearing loss, in both males and females (p < 0.001) and in subjects whose body mass indices (BMI) were less than 30 (p < 0.001). In conclusion, ALP may play a role in detecting hearing loss.
听力损失随着年龄的增长而越来越普遍，影响生活质量。最近，科学家们发表了一些关于代谢性疾病与听力损失之间关系的文章。以前发现代谢性疾病与碱性磷酸酶的升高高度相关。因此，碱性磷酸酶（ALP）和听力损失之间可能存在间接关系。在本文中，我们将展示 ALP 与听力损失之间的关系。我们纳入了 3877 名美国全国健康和营养检查调查（NHANES）参与者，他们代表美国 20 至 69 岁的非机构化平民人口，并检查了 ALP 与纯音空气条件（PTAC）阈值频率分布之间的关联。在调整了相关变量后，属于 ALP 较高四分位的受试者的听力阈值（高频和低频的纯音平均值）比 ALP 的第一四分位差（p < 0.001）。结果表明，ALP 与听力损失之间呈正相关，无论男女（p < 0.001）以及 BMI 小于 30 的受试者（p < 0.001）中均如此。总之，ALP 可能在检测听力损失方面发挥作用。
