Jung Da Jung, Cho Hyun Ho, Lee Kyu-Yup
Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
Clin Exp Otorhinolaryngol. 2016 Dec;9(4):319-325. doi: 10.21053/ceo.2015.01858. Epub 2016 May 3.
Previous studies examining the association between osteoporosis (OP) and hearing loss (HL) have shown conflicting results. The objective of the present study was to examine the association between hearing impairment and OP in postmenopausal women, using appropriate statistical analyses.
Total 1,009 participants were included in the current study. The propensity score matched (PSM) cohort was defined as the cohort including participants diagnosed with OP and participants without OP. Three statistical models were developed where model 1 was unadjusted, model 2 included age, and model 3 included age, body mass index, alcohol intake, smoking habit, diabetes mellitus, hypertension, high density lipoprotein cholesterol, triglyceride level, vitamin D, and alkaline phosphatase.
There were 776 and 233 participants in the groups diagnosed without and with OP, respectively. For propensity score matching, 233 pairs were selected from the 776 participants without OP. In the total cohort, using statistical models 2 and 3, no significant difference in the four hearing thresholds was identified between the 2 groups. Logistic regression indicated that, in model 3, participants with OP had a 1.128 (=0.323) increased risk HL. A significant HL risk was not observed in participants with OP. Using statistical model 3, there were no significant associations among lumbar spine or femoral neck T-scores and changes in the hearing thresholds. In the PSM cohort, statistical models also showed similar results.
The current study did not demonstrate and association between bone mineral density and hearing impairment in the study population of postmenopausal Korean women.
以往研究骨质疏松症（OP）与听力损失（HL）之间关联的结果相互矛盾。本研究的目的是通过适当的统计分析，探讨绝经后女性听力障碍与OP之间的关联。
本研究共纳入1009名参与者。倾向评分匹配（PSM）队列定义为包括被诊断为OP的参与者和未患OP的参与者的队列。建立了三个统计模型，模型1未进行调整，模型2纳入了年龄，模型3纳入了年龄、体重指数、酒精摄入量、吸烟习惯、糖尿病、高血压、高密度脂蛋白胆固醇、甘油三酯水平、维生素D和碱性磷酸酶。
在未诊断为OP和诊断为OP的组中，分别有776名和233名参与者。对于倾向评分匹配，从776名未患OP的参与者中选择了233对。在整个队列中，使用统计模型2和3，两组之间的四个听力阈值没有显著差异。逻辑回归表明，在模型3中，患有OP的参与者患HL的风险增加了1.128（=0.323）。在患有OP的参与者中未观察到显著的HL风险。使用统计模型3，腰椎或股骨颈T评分与听力阈值变化之间没有显著关联。在PSM队列中，统计模型也显示了类似的结果。
本研究未证明韩国绝经后女性研究人群中骨密度与听力障碍之间存在关联。
