Storch W, Keitel W
Institut für Immunologie und Serologie der Universität Heidelberg.
Z Rheumatol. 1988;47 Suppl 1:44-7.
Antibodies to D-penicillamine (DPA) were determined in 25 patients with classic rheumatoid arthritis being treated with DPA. Positive results were found before and during therapy with DPA. Antibodies were found in seven out of ten patients without the desired therapeutic effects; in five cases before starting the therapy. It is hypothesized that antibodies against drugs are heterogeneous and influence the effect of the drugs, e.g. inhibition of the desired effect and stimulation of an undesired (adverse) reaction.
在25例接受青霉胺（DPA）治疗的典型类风湿性关节炎患者中检测了抗青霉胺（DPA）抗体。在使用DPA治疗前和治疗期间均发现了阳性结果。在10例未获得预期治疗效果的患者中，有7例检测到抗体；其中5例在开始治疗前就已检测到。据推测，药物抗体具有异质性，并会影响药物的疗效，例如抑制预期效果并引发非预期（不良）反应。
