Devogelaer J P, Isaac G, Noël H, De Bruyère M, Huaux J P, Nagant de Deuxchaisnes C
Int J Clin Pharmacol Res. 1985;5(3):143-7.
Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis. The cumulative doses responsible for the three DPA-induced MG cases amounted respectively to 73, 117 and 467 g. The cumulative dose responsible for the DPA-induced PM case amounted to 465 g. All the patients were HLA DR1. All four cases healed completely after withdrawal of DPA. The aetiology of the cases is discussed and the literature is reviewed. These cases represent further instances of DPA-induced neuromuscular disorders.
在4例血清阳性类风湿性关节炎患者中，报告了3例因青霉胺（DPA）诱发的重症肌无力（MG）和1例因DPA诱发的多发性肌炎（PM）。导致3例DPA诱发MG病例的累积剂量分别为73克、117克和467克。导致DPA诱发PM病例的累积剂量为465克。所有患者均为HLA DR1。所有4例患者在停用DPA后均完全康复。对病例的病因进行了讨论并回顾了相关文献。这些病例代表了DPA诱发的神经肌肉疾病的更多实例。
