Nayeri Nahid Dehghan, Bakhshi Fatemeh, Khosravi Afifeh, Najafi Zahra
Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Indian J Palliat Care. 2020 Jan-Mar;26(1):95-104. doi: 10.4103/IJPC.IJPC_183_19. Epub 2020 Jan 28.
Breast cancer disease and its classic treatment lead to decrease in patients' quality of life (QOL). This systematic review aimed to compare the effectiveness of complementary and alternative medicines (CAMs) categories on the QOL of women with breast cancer.
English clinical trials from PubMed, Emabase, Scupos, and Google Scholar databases were searched electronically by the end of 2018 with the Cochrane Collaboration protocol. Two researchers independently extracted data such as participants' characteristics, CAM methods, QOL assessment tools. CAMs were classified into three categories of dietary supplements, herbal medicine, and mind-body techniques.
During the initial search, 1186 articles were found. After reviewing titles, abstracts, and full texts based on inclusion and exclusion criteria, 28 clinical trials were included in the systematic review, 18 of which was randomized controlled trial (RCT). Participants included women with breast cancer who were undergoing the first three phases of breast cancer or postcancer rehabilitation. Among CAM interventions, one article used a dietary supplement, and the other 27 articles included a variety of mind-body techniques. Twenty-seven studies showed improved QOL ( > 0.05).
The findings may indicate the potential benefits of CAMs, especially mind-body techniques on QOL in breast cancer patients. Further RCTs or long-term follow-up studies are recommended. Moreover, the use of similar QOL assessment tools allows for more meta-analysis and generalizability of results, especially for the development of clinical guidelines.
乳腺癌疾病及其传统治疗方法会导致患者生活质量（QOL）下降。本系统评价旨在比较补充和替代医学（CAMs）各类别对乳腺癌女性患者生活质量的有效性。
截至2018年底，按照Cochrane协作网方案，通过电子检索PubMed、Embase、Scupos和谷歌学术数据库中的英文临床试验。两名研究人员独立提取诸如参与者特征、CAM方法、生活质量评估工具等数据。CAMs被分为膳食补充剂、草药和身心技术三类。
在初步检索过程中，共找到1186篇文章。根据纳入和排除标准对标题、摘要和全文进行审查后，28项临床试验被纳入本系统评价，其中18项为随机对照试验（RCT）。参与者包括正在接受乳腺癌前三期治疗或癌症康复后的乳腺癌女性患者。在CAM干预措施中，1篇文章使用了膳食补充剂，其他27篇文章纳入了多种身心技术。27项研究显示生活质量有所改善（>0.05）。
研究结果可能表明CAMs，尤其是身心技术对乳腺癌患者生活质量具有潜在益处。建议开展进一步的随机对照试验或长期随访研究。此外，使用相似的生活质量评估工具可进行更多的荟萃分析并提高结果的普遍性，特别是对于临床指南的制定。
