Kroh H, Stoltenburg-Didinger G
Department of Neuropathology, Polish Academy of Sciences, Warsaw, Poland.
Zentralbl Allg Pathol. 1988;134(6):523-30.
Reported is the immunoreactivity of tumoral and peritumoral vessels of 7 spinal cord gliomas induced in rats by means of ethylnitrosourea. Immunostaining for Factor VIII/RAg has been more strongly pronounced in endothelial cells of newly formed vessels at the tumor periphery, in comparison with tumoral vessels, and this is likely to suggest a differentiation process during extensive neovascularization of the tumor periphery. Endothelial distribution of vimentin in the peripheral vessels is more intensive than within the tumors, suggesting its relation to rapid new blood vessel formation. Immunostaining for GFAP and vimentin overlaps in astrocytes trapped within neoplasms, in astrocytes at the tumor periphery, and in the peritumoral zone.
报告了通过乙基亚硝基脲在大鼠中诱导产生的7例脊髓胶质瘤的肿瘤血管和肿瘤周围血管的免疫反应性。与肿瘤血管相比，肿瘤周边新生血管内皮细胞中因子VIII/RAg的免疫染色更为明显，这可能表明在肿瘤周边广泛新生血管形成过程中存在分化过程。波形蛋白在周边血管中的内皮分布比肿瘤内部更密集，表明其与快速形成新血管有关。在肿瘤内被困的星形胶质细胞、肿瘤周边的星形胶质细胞以及肿瘤周围区域，GFAP和波形蛋白的免疫染色相互重叠。
