Kroh H
Acta Neuropathol. 1987;73(1):92-8. doi: 10.1007/BF00695507.
The histology and ultrastructure of ten spinal cord gliomas, mainly oligodendrogliomas, induced transplacentally in rat with ethylnitrosourea were studied. The characteristic feature of seven spinal tumours was distinct delineation of neoplastic tissue from the edematous surrounding zone by a ring of irregular, proliferating capillaries, among which immature capillary buds prevailed. The alterations were proliferation of endothelium with endothelial overlapping, elongation of interendothelial junctions and enhancement of pinocytotic vesicles on luminal and abluminal surfaces. The basal membranes, besides other changes, were often replaced by some floccular condensations. In the edematous zone the capillary walls were deprived of contact with glial processes. The lack of contact between astrocytic processes and vascular wall may contribute to the persistent immature state of peripheral capillaries.
对10例经胎盘注射乙基亚硝基脲诱导产生的大鼠脊髓胶质瘤（主要为少突胶质细胞瘤）的组织学和超微结构进行了研究。7例脊髓肿瘤的特征性表现是，肿瘤组织与周围水肿区之间由一圈不规则增生的毛细血管清晰分隔，其中以不成熟的毛细血管芽为主。这些改变包括内皮细胞增殖并相互重叠、内皮细胞间连接延长以及管腔面和管腔外表面的胞饮小泡增多。除其他变化外，基底膜常被一些絮状沉积物取代。在水肿区，毛细血管壁与胶质细胞突起失去接触。星形胶质细胞突起与血管壁缺乏接触可能导致外周毛细血管持续处于不成熟状态。
