用于史密斯-勒米-奥皮茨综合征的他汀类药物。
Statins for Smith-Lemli-Opitz syndrome.
作者信息
Ballout Rami A, Bianconi Simona, Livinski Alicia, Fu Yi-Ping, Remaley Alan T, Porter Forbes D
机构信息
Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
National Institute of Child Health and Development, NIH, Bethesda, USA.
出版信息
Cochrane Database Syst Rev. 2020;2020(1). doi: 10.1002/14651858.cd013521.
Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: 1. To evaluate the efficacy of statin therapy in reducing the frequency or severity of the neurobehavioral abnormalities seen in people with SLOS (e.g. aggression, anxiety, irritability, self-mutilation, autistic behaviors, sleep disturbances, etc.) (Wassif 2017). 2. To evaluate the potential effects of statin therapy on survival.
摘要
这是一项Cochrane系统评价（干预措施）的方案。目标如下：1. 评估他汀类药物治疗对降低Smith-Lemli-Opitz综合征（SLOS）患者出现的神经行为异常的频率或严重程度（如攻击行为、焦虑、易怒、自残、自闭症行为、睡眠障碍等）的疗效（瓦西夫，2017年）。2. 评估他汀类药物治疗对生存的潜在影响。
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