Hasani-Ranjbar Shirin, Jafari-Adli Shahrzad, Payab Moloud, Qorbani Mostafa, Ahanjideh Farzaneh, Keshtkar Abbasali, Larijani Bagher
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2019 Oct 9;10:157. doi: 10.4103/ijpvm.IJPVM_326_17. eCollection 2019.
Osteoporosis and obesity are two major public health problems worldwide. Considering the conflicting results about the association between anthropometric measurement and bone mineral density (BMD) and also differences between various races, this study was designed to examine the relationship between anthropometric measurements and BMD in a sample of Iranian adults.
This cross-sectional population-based study was conducted on 2625 Iranian adults aged 18 and above who were selected using multistage, cluster sampling method from Sanandaj and Arak (two cities of Iran). The evaluated variables included age, sex, height, weight, body mass index (BMI), BMD, and waist and hip circumferences. The correlations between anthropometric measures and BMD in three bone areas (total hip, femoral neck, and spine) were observed in four sex/age groups (men <50 years, men ≥50 years, and pre- and postmenopausal women).
Of all the 2625 participants in the Iranian Multicenter Osteoporosis Study, 2022 (1303 women and 719 men) entered into our survey and were stratified into four sex/age groups. According to the results, increasing BMI was directly associated with BMD increase, while an inverse association was observed between waist-to-hip ratio (WHR) and total hip BMD. In a similar analysis on the femoral neck and WHR, the correlation coefficients in premenopausal women and men ≥50 years were reported as being the highest and the lowest, respectively, among the four groups.
Our results showed that high BMI is a protective factor (positive correlation), and high WHR is a risk factor for osteoporosis, although it should be reminded that we could not specifically define which factors including lean tissue mass, fat mass, and total weight are really affecting BMD increase in the overweight/obese participants.
骨质疏松症和肥胖是全球两个主要的公共卫生问题。鉴于人体测量指标与骨密度（BMD）之间关联的研究结果相互矛盾，且不同种族之间也存在差异，本研究旨在调查伊朗成年人样本中人体测量指标与骨密度之间的关系。
本基于人群的横断面研究对2625名18岁及以上的伊朗成年人进行，这些人采用多阶段整群抽样方法从伊朗的两个城市（萨南达杰和阿拉克）选取。评估变量包括年龄、性别、身高、体重、体重指数（BMI）、骨密度以及腰围和臀围。在四个性别/年龄组（年龄<50岁的男性、年龄≥50岁的男性以及绝经前和绝经后女性）中观察了三个骨区域（全髋、股骨颈和脊柱）的人体测量指标与骨密度之间的相关性。
在伊朗多中心骨质疏松症研究的所有2625名参与者中，2022人（1303名女性和719名男性）进入我们的调查，并被分为四个性别/年龄组。根据结果，BMI增加与骨密度增加直接相关，而腰臀比（WHR）与全髋骨密度之间呈负相关。在对股骨颈和WHR的类似分析中，绝经前女性和年龄≥50岁的男性组的相关系数在四组中分别为最高和最低。
我们的结果表明，高BMI是骨质疏松症的一个保护因素（正相关），而高WHR是一个风险因素，不过需要提醒的是，我们无法具体确定在超重/肥胖参与者中，包括瘦组织质量、脂肪质量和总体重在内的哪些因素真正影响骨密度增加。
