Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, China.
Clin Endocrinol (Oxf). 2011 Mar;74(3):319-24. doi: 10.1111/j.1365-2265.2010.03941.x.
To elucidate the relationship between body composition and bone mineral density (BMD) and the prevalence of osteoporosis in central south Chinese postmenopausal women.
A cross-sectional study was conducted on 954 healthy central southern Chinese postmenopausal women, aged 50-82. Total body, lumbar spine and left femur BMD and total body soft tissue composition were measured by dual X-ray absorptiometry.
Among the study population, 578 (60.5%) subjects were without osteoporosis and 376 (39.4%) subjects were osteoporotic. The osteoporotic women were older, shorter and thinner, had an earlier age at menopause, a lower BMD and bone mineral content (BMC) of the total body and at different sites, and had lower body mass and body mass components than the women without osteoporosis. Both fat mass and lean mass were positively correlated with age at menopause, height, weight, body mass index (BMI) and BMD at all sites. Fat mass and lean mass were also inversely correlated with age and years since menopause (P<0.05). After controlling for age, age at menopause and height, both fat mass and lean mass were positively correlated with BMD at the lumbar(1-4) spine, the femoral neck and the total hip. Fat mass was the most significant determinant of BMD at the lumbar(1-4) spine with a higher R(2) change and a partial R(2) compared with that of lean mass, while lean mass had more impact on the total hip values. Either a fat mass below 18.4 kg or a lean mass below 33.9 kg was correlated with a higher prevalence of osteoporosis at the lumbar spine or total hip.
In central south Chinese postmenopausal women, both fat mass and lean mass are correlated with BMD at the lumbar spine and hip. Fat mass was the most significant determinant of BMD at the lumbar spine, while lean mass had more impact on the total hip value. Both lower values of fat mass and lean mass are related to a higher prevalence of osteoporosis at either the lumbar spine or the total hip. Thus, it is important to maintain a reasonable body weight to balance bone health and other metabolic disorders.
阐明中南地区绝经后妇女体成分与骨密度（BMD）及骨质疏松症患病率之间的关系。
对 954 名年龄在 50-82 岁的健康中南地区绝经后妇女进行了横断面研究。采用双能 X 线吸收仪测量全身、腰椎和左侧股骨的 BMD 及全身软组织成分。
在研究人群中，578 名（60.5%）受试者无骨质疏松症，376 名（39.4%）受试者患有骨质疏松症。骨质疏松症女性年龄较大、身材较矮较瘦，绝经年龄较早，全身及不同部位的 BMD 和骨矿物质含量（BMC）较低，体质量及体质量成分较低。脂肪量和瘦体量均与绝经年龄、身高、体重、体重指数（BMI）和各部位 BMD 呈正相关。脂肪量和瘦体量与年龄和绝经年限也呈负相关（P<0.05）。在控制年龄、绝经年龄和身高后，脂肪量和瘦体量与腰椎（1-4）、股骨颈和全髋 BMD 均呈正相关。脂肪量是腰椎（1-4）BMD 的最显著决定因素，其 R²变化和偏 R²均高于瘦体量，而瘦体量对全髋值的影响更大。脂肪量低于 18.4kg 或瘦体量低于 33.9kg 与腰椎或全髋骨质疏松症患病率升高相关。
在中南地区绝经后妇女中，脂肪量和瘦体量均与腰椎和髋部 BMD 相关。脂肪量是腰椎 BMD 的最显著决定因素，而瘦体量对全髋值的影响更大。脂肪量和瘦体量均较低与腰椎或全髋骨质疏松症患病率升高有关。因此，保持合理的体重对于平衡骨骼健康和其他代谢紊乱非常重要。
