Li Mingjing, Wang Zhaoyu, Yan Bocheng, Yin Xiaona, Zhao Yue, Yu Fan, Meng Meng, Liu Yonghui, Zhao Wei
State Key Laboratory of Medicinal Chemical Biology , College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research , Nankai University , Haihe Education Park, 38 Tongyan Road , Tianjin , 300350 , P. R. China . Email:
College of Life Sciences , Nankai University , Nankai District, 94 Weijin Road , Tianjin , 300071 , P. R. China.
Medchemcomm. 2019 Jul 12;10(12):2073-2077. doi: 10.1039/c9md00254e. eCollection 2019 Dec 1.
MUC1 is an attractive target for cancer vaccines as a result of its over-expression and aberrant glycosylation pattern on many tumor cells. However, the low immunogenicity of MUC1 and immune tolerance have limited its application. Herein, we designed MUC1-based tricomponent antitumor vaccines adjuvanted with fibroblast stimulating lipopeptide 1 (FSL-1). Immunological results indicate that the glycosylated tricomponent vaccine candidate has elicited both humoral and cellular immune responses. The induced antibodies could effectively bind to MCF-7. Furthermore, the vaccine exhibited an obvious reduction in tumour burden.
由于MUC1在许多肿瘤细胞上过度表达且糖基化模式异常,它是癌症疫苗的一个有吸引力的靶点。然而,MUC1的低免疫原性和免疫耐受性限制了其应用。在此,我们设计了以MUC1为基础、佐以成纤维细胞刺激脂肽1(FSL-1)的三组分抗肿瘤疫苗。免疫学结果表明,糖基化的三组分候选疫苗引发了体液免疫和细胞免疫反应。诱导产生的抗体能够有效结合MCF-7。此外,该疫苗使肿瘤负荷明显降低。