Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
J Cell Mol Med. 2020 Sep;24(18):10279-10289. doi: 10.1111/jcmm.15684. Epub 2020 Aug 3.
Mucins are a family of multifunctional glycoproteins that mostly line the surface of epithelial cells in the gastrointestinal tract and exert pivotal roles in gut lubrication and protection. Pancreatic cancer is a lethal disease with poor early diagnosis, limited therapeutic effects, and high numbers of cancer-related deaths. In this review, we introduce the expression profiles of mucins in the normal pancreas, pancreatic precursor neoplasia and pancreatic cancer. Mucins in the pancreas contribute to biological processes such as the protection, lubrication and moisturization of epithelial tissues. They also participate in the carcinogenesis of pancreatic cancer and are used as diagnostic biomarkers and therapeutic targets. Herein, we discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment to gain a better understanding of the role of mucins in pancreatic cancer.
黏蛋白是一类多功能糖蛋白家族，主要分布在胃肠道上皮细胞表面，在肠道润滑和保护中发挥关键作用。胰腺癌是一种致命性疾病，早期诊断困难，治疗效果有限，癌症相关死亡率高。在这篇综述中，我们介绍了黏蛋白在正常胰腺、胰腺前体肿瘤和胰腺癌中的表达谱。胰腺中的黏蛋白有助于上皮组织的保护、润滑和保湿等生物学过程。它们还参与了胰腺癌的发生，可用作诊断生物标志物和治疗靶点。本文讨论了黏蛋白导致胰腺腺癌致命性的重要作用，特别是 MUC1、MUC4、MUC5AC 和 MUC16 在疾病进展中的作用，并对黏蛋白的临床应用及其在癌症治疗中的有前途的作用进行了全面分析，以更好地了解黏蛋白在胰腺癌中的作用。
