Consolino Lorena, Anemone Annasofia, Capozza Martina, Carella Antonella, Irrera Pietro, Corrado Alessia, Dhakan Chetan, Bracesco Martina, Longo Dario Livio
Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany.
Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Turin, Italy.
Front Oncol. 2020 Feb 18;10:161. doi: 10.3389/fonc.2020.00161. eCollection 2020.
Altered metabolism is considered a core hallmark of cancer. By monitoring metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.
代谢改变被认为是癌症的核心特征。通过监测代谢物变化或表征肿瘤微环境，非侵入性成像方法在阐明肿瘤生物学的多个方面发挥着重要作用。在磁共振成像（MRI）模态中，化学交换饱和转移（CEST）方法已成为一种新技术，为肿瘤代谢和酸中毒成像提供了高空间分辨率和灵敏度。本综述介绍了基于CEST的非侵入性研究肿瘤代谢和相关重要代谢物（如葡萄糖和乳酸）的方法，以及肿瘤酸中毒的测量。还将针对每种特定技术报告已用于评估抗癌治疗反应的方法。
