Holford Nick
Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Transl Clin Pharmacol. 2017 Jun;25(2):59-62. doi: 10.12793/tcp.2017.25.2.59. Epub 2017 Jun 15.
This tutorial describes sources of pharmacokinetic variability that are not obviously linked to genetic differences. The sources of variability are therefore described as environmental. The major quantitative sources of environmental variability are body size (including body composition), maturation and organ function. Size should be considered in all patients. Maturation is mainly relevant to neonates and infants less than 2 years of age. Renal function is the most important predictable source of variability due to differences in organ function.
本教程描述了与基因差异无明显关联的药代动力学变异性来源。因此，这些变异性来源被描述为环境因素。环境变异性的主要定量来源包括体型（包括身体组成）、成熟度和器官功能。所有患者都应考虑体型因素。成熟度主要与新生儿和2岁以下婴儿相关。由于器官功能差异，肾功能是变异性最重要的可预测来源。
