• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Organoid Models of Human Endometrial Development and Disease.

作者信息

Hibaoui Youssef, Feki Anis

机构信息

Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.

Service de Gynécologie Obstétrique, HFR Fribourg - Hôpital Cantonal, Fribourg, Switzerland.

出版信息

Front Cell Dev Biol. 2020 Feb 18;8:84. doi: 10.3389/fcell.2020.00084. eCollection 2020.

DOI:10.3389/fcell.2020.00084
PMID:32133360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7039834/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/7039834/1a06ef4be94d/fcell-08-00084-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/7039834/1a06ef4be94d/fcell-08-00084-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0743/7039834/1a06ef4be94d/fcell-08-00084-g0001.jpg

相似文献

1
Organoid Models of Human Endometrial Development and Disease.人类子宫内膜发育与疾病的类器官模型
Front Cell Dev Biol. 2020 Feb 18;8:84. doi: 10.3389/fcell.2020.00084. eCollection 2020.
2
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.子宫内膜疾病衍生的类器官可捕获临床异质性并适用于药物筛选。
Nat Cell Biol. 2019 Aug;21(8):1041-1051. doi: 10.1038/s41556-019-0360-z. Epub 2019 Aug 1.
3
[Differential expression of microRNA in eutopic endometrium tissue during implantation window for patients with endometriosis related infertility].[子宫内膜异位症相关性不孕患者着床窗期在位内膜组织中微小RNA的差异表达]
Zhonghua Fu Chan Ke Za Zhi. 2016 Jun 25;51(6):436-41. doi: 10.3760/cma.j.issn.0529-567X.2016.06.007.
4
MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer.MRP4 维持 Wnt/β-连环蛋白信号转导以支持妊娠、子宫内膜异位症和子宫内膜癌。
Theranostics. 2019 Jul 9;9(17):5049-5064. doi: 10.7150/thno.32097. eCollection 2019.
5
Human Cytomegalovirus Compromises Development of Cerebral Organoids.人类巨细胞病毒损害脑类器官的发育。
J Virol. 2019 Aug 13;93(17). doi: 10.1128/JVI.00957-19. Print 2019 Sep 1.
6
Self-renewing endometrial epithelial organoids of the human uterus.人类子宫的自我更新子宫内膜类器官。
Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23132-23142. doi: 10.1073/pnas.1915389116. Epub 2019 Oct 30.
7
Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells.利用源自人类诱导多能干细胞的 3D 类器官进行疾病建模。
Int J Mol Sci. 2018 Mar 21;19(4):936. doi: 10.3390/ijms19040936.
8
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability.从小鼠和人类子宫内膜培育类器官，展现子宫内膜上皮生理学特性及长期可扩展性。
Development. 2017 May 15;144(10):1775-1786. doi: 10.1242/dev.148478. Epub 2017 Apr 25.
9
Is the profile of transcripts altered in the eutopic endometrium of infertile women with endometriosis during the implantation window?在着床窗口期，患有子宫内膜异位症的不孕妇女的在位子宫内膜的转录本特征是否改变？
Hum Reprod. 2019 Dec 1;34(12):2381-2390. doi: 10.1093/humrep/dez225.
10
Regenerating endometrium from stem/progenitor cells: is it abnormal in endometriosis, Asherman's syndrome and infertility?从干细胞/祖细胞再生子宫内膜：在子宫内膜异位症、Asherman 综合征和不孕中是否异常？
Curr Opin Obstet Gynecol. 2013 Jun;25(3):193-200. doi: 10.1097/GCO.0b013e32836024e7.

引用本文的文献

1
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research.子宫内膜异位症研究实验模型的WERF子宫内膜异位症表型与生物样本库协调项目（EPHect-EM-类器官）：子宫内膜类器官作为子宫内膜异位症研究的一项新兴技术。
Mol Hum Reprod. 2025 Jul 3;31(3). doi: 10.1093/molehr/gaaf024.
2
Endometrial Organoids and Their Role in Modeling Human Infertility.子宫内膜类器官及其在人类不孕症建模中的作用。
Cells. 2025 Jun 3;14(11):829. doi: 10.3390/cells14110829.
3
The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors.

本文引用的文献

1
Clinical actionability of molecular targets in endometrial cancer.子宫内膜癌中分子靶标的临床可操作性。
Nat Rev Cancer. 2019 Sep;19(9):510-521. doi: 10.1038/s41568-019-0177-x. Epub 2019 Aug 6.
2
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.子宫内膜疾病衍生的类器官可捕获临床异质性并适用于药物筛选。
Nat Cell Biol. 2019 Aug;21(8):1041-1051. doi: 10.1038/s41556-019-0360-z. Epub 2019 Aug 1.
3
Engineering Stem Cell Self-organization to Build Better Organoids.
PENDOR研究：建立一组源自子宫内膜癌患者的肿瘤类器官以评估PARP抑制剂的疗效。
BMC Cancer. 2025 Feb 11;25(1):244. doi: 10.1186/s12885-025-13590-6.
4
Biotechnological progresses in modelling the human endometrium: the evolution of current techniques and emerging trends.人类子宫内膜建模的生物技术进展：当前技术的演变与新趋势
Front Bioeng Biotechnol. 2024 Dec 3;12:1495338. doi: 10.3389/fbioe.2024.1495338. eCollection 2024.
5
The modeling of human implantation and early placentation: achievements and perspectives.人类着床和早期胎盘形成的建模：成就与展望
Hum Reprod Update. 2025 Mar 1;31(2):133-163. doi: 10.1093/humupd/dmae033.
6
Generation and Maintenance of Patient-Derived Endometrial Cancer Organoids.患者来源的子宫内膜癌类器官的生成与维持。
Bio Protoc. 2024 Oct 20;14(20):e5093. doi: 10.21769/BioProtoc.5093.
7
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.利用DNA编码化学技术鉴定有效的泛肾上腺素受体激酶抑制剂。
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121. doi: 10.1073/pnas.2322934121. Epub 2024 May 3.
8
Advanced Technologies for Studying Microbiome-Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond.研究微生物组-女性生殖道相互作用的先进技术：类器官、类器官芯片及其他。
Semin Reprod Med. 2023 Sep;41(5):160-171. doi: 10.1055/s-0043-1778067. Epub 2024 Jan 23.
9
Endometrial organoids: a reservoir of functional mitochondria for uterine repair.子宫内膜类器官：子宫修复的功能性线粒体库。
Theranostics. 2024 Jan 1;14(3):954-972. doi: 10.7150/thno.90538. eCollection 2024.
10
Human Endometrium Derived Induced Pluripotent Stem Cells Are Amenable to Directed Erythroid Differentiation.人子宫内膜诱导多能干细胞易于定向红系分化。
Tissue Eng Regen Med. 2023 Oct;20(6):939-950. doi: 10.1007/s13770-023-00554-9. Epub 2023 Jul 15.
工程化干细胞自组织构建更好的类器官
Cell Stem Cell. 2019 Jun 6;24(6):860-876. doi: 10.1016/j.stem.2019.05.005.
4
Trophoblast organoids as a model for maternal-fetal interactions during human placentation.滋养层类器官作为人类胎盘发生过程中母胎相互作用的模型。
Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018-0753-3. Epub 2018 Nov 28.
5
Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway.从人诱导多能干细胞生成孕激素反应性子宫内膜基质成纤维细胞：WNT/CTNNB1 通路的作用。
Stem Cell Reports. 2018 Nov 13;11(5):1136-1155. doi: 10.1016/j.stemcr.2018.10.002. Epub 2018 Nov 1.
6
Optimization of Endometrial Decidualization in the Menstruating Mouse Model for Preclinical Endometriosis Research.用于临床前子宫内膜异位症研究的月经小鼠模型中子宫内膜蜕膜化的优化。
Reprod Sci. 2018 Nov;25(11):1577-1588. doi: 10.1177/1933719118756744. Epub 2018 Feb 18.
7
International Patterns and Trends in Endometrial Cancer Incidence, 1978-2013.国际子宫内膜癌发病率的模式和趋势，1978-2013 年。
J Natl Cancer Inst. 2018 Apr 1;110(4):354-361. doi: 10.1093/jnci/djx214.
8
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability.从小鼠和人类子宫内膜培育类器官，展现子宫内膜上皮生理学特性及长期可扩展性。
Development. 2017 May 15;144(10):1775-1786. doi: 10.1242/dev.148478. Epub 2017 Apr 25.
9
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.在化学成分明确的培养基中对人子宫内膜进行长期的、激素反应性类器官培养。
Nat Cell Biol. 2017 May;19(5):568-577. doi: 10.1038/ncb3516. Epub 2017 Apr 10.
10
Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease.人类多能干细胞作为正常发育和疾病中滋养层分化的模型。
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3882-91. doi: 10.1073/pnas.1604747113. Epub 2016 Jun 20.