Shetty Robin, Rai Mohandas, Chandrashekar Rajan, Kalal Bhuvanesh Sukhlal
Department of Pharmacology, A. J. Institute of Medical Sciences and Research Centre, Mangaluru-575004, Karnataka, India.
A. J. Research Centre, A. J. Institute of Medical Sciences and Research Centre, Mangaluru-575004, Karnataka, India.
Med Pharm Rep. 2020 Jan;93(1):47-52. doi: 10.15386/mpr-1373. Epub 2020 Jan 31.
Gluten-related disease affects less than 1% population and is not considered of relevance at the public health level. However, the consumption of a gluten-free diet has been most commonly adopted as a special diet worldwide in the recent past. In the present study, we investigated the association of gluten intake and diabetes in Wistar albino rats.
Thirty adult Wistar rats were randomly divided into five groups: control, diabetic, and test treated with pure gluten (100, 200 and 400 mg/kg body weight). Diabetes was induced in rats by intraperitoneal injection of Streptozotocin (65 mg/kg) after a dose of nicotinamide (110 mg/kg). Body weight, fasting blood glucose levels, postprandial blood glucose levels and histopathology of the pancreas were compared.
Fasting blood glucose levels and postprandial blood glucose were significantly higher in diabetes animals but there were no significant changes in gluten treated groups. Other parameters were not significantly changed among different groups.
Gluten at doses 100 mg/kg, 200 mg/kg and 400 mg/kg is not a diabetogenic diet and hence it needs not be excluded from diet for the prevention and management of Type 2 diabetes mellitus.
麸质相关疾病影响不到1%的人群，在公共卫生层面不被视为具有相关性。然而，无麸质饮食在最近已成为全球最普遍采用的一种特殊饮食。在本研究中，我们调查了Wistar白化大鼠的麸质摄入量与糖尿病之间的关联。
30只成年Wistar大鼠被随机分为五组：对照组、糖尿病组以及分别用纯麸质（100、200和400毫克/千克体重）处理的试验组。在给予烟酰胺（110毫克/千克）剂量后，通过腹腔注射链脲佐菌素（65毫克/千克）诱导大鼠患糖尿病。比较了体重、空腹血糖水平、餐后血糖水平以及胰腺的组织病理学。
糖尿病动物的空腹血糖水平和餐后血糖显著更高，但麸质处理组无显著变化。不同组之间的其他参数无显著改变。
100毫克/千克、200毫克/千克和400毫克/千克剂量的麸质不是致糖尿病饮食，因此在预防和管理2型糖尿病时无需从饮食中排除。
