Division of Infectious Diseases and Department of Infection Control, Tokyo Metropolitan Tama Medical Center, Fuchu, Tokyo, Japan.
Muribushi Project for Teaching Hospitals, Iso, Urasoe, Okinawa, Japan.
Clin Infect Dis. 2020 Oct 23;71(7):1783-1789. doi: 10.1093/cid/ciaa216.
The shortage of antimicrobials poses a global health threat. In Japan, for instance, the current, critical shortage of cefazolin, a first-line agent for the treatment of common infectious diseases and surgical antimicrobial prophylaxis, has had a substantial impact on inpatient care. A shortage of essential antimicrobial agents like cefazolin leads to increased consumption of alternative antimicrobial agents with broad-spectrum activity, with the unintended consequence of militating against antimicrobial stewardship efforts in inpatient settings and potentially promoting antimicrobial resistance. Although there is global awareness of the shortage of crucial antimicrobials, action to resolve this problem, especially with a view to preventing antimicrobial resistance and promoting antimicrobial stewardship, has been slow, possibly due to the failure to appreciate the urgency of the dilemma. A comprehensive plan for stabilizing antimicrobial access and international collaboration to secure a continuous supply of essential antimicrobials are urgently needed.
抗菌药物短缺对全球健康构成威胁。例如，在日本，作为治疗常见传染病和外科手术抗菌预防一线药物的头孢唑林目前严重短缺，这对住院治疗产生了重大影响。像头孢唑林这样的基本抗菌药物短缺会导致广谱活性的替代抗菌药物的消耗增加，这无意中阻碍了住院环境中的抗菌药物管理工作，并可能促进抗菌药物耐药性的产生。尽管全球对抗菌药物短缺问题有一定的认识，但采取行动解决这一问题，特别是为了预防抗菌药物耐药性和促进抗菌药物管理，一直进展缓慢，这可能是由于未能认识到这一困境的紧迫性。迫切需要制定一项稳定抗菌药物供应的综合计划，并开展国际合作，以确保基本抗菌药物的持续供应。
