3,4-二氢-1,4-苯并恶嗪-2-酮的过氧化作用。

Peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones.

机构信息

Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.

出版信息

Chem Commun (Camb). 2020 Apr 7;56(27):3895-3898. doi: 10.1039/c9cc09778c. Epub 2020 Mar 5.

DOI:10.1039/c9cc09778c

PMID:32134057

Abstract

The sp-C-H peroxidation of 3,4-dihydro-1,4-benzoxazin-2-ones was achieved under mild and simple catalyst-free reaction conditions. A range of biologically important alkylated benzoxazinone peroxides are synthesized in high yield with a good functional group tolerance. The C(sp)-OO bond was constructed efficiently and could be further converted into C(sp)-C(sp), C(sp)-C(sp), C(sp)-C(sp), C-P and C[double bond, length as m-dash]O bonds by late-stage functional group transformations.

摘要

3,4-二氢-1,4-苯并恶嗪-2-酮的 sp-C-H 过氧反应在温和且简单的无催化剂反应条件下实现。在高收率和良好官能团容忍度的条件下，合成了一系列具有重要生物学意义的烷基化苯并恶嗪酮过氧化物。C(sp)-OO 键的构建效率高，可以通过后期的官能团转化进一步转化为 C(sp)-C(sp)、C(sp)-C(sp)、C(sp)-C(sp)、C-P 和 C[双键，长度为 m-dash]O 键。