Unit of Health, Medical and Neuropsychology, Institute of Psychology, Faculty of Social and Behavioural Sciences, Leiden University.
Department of Psychiatry, University of Oxford.
J Consult Clin Psychol. 2020 Apr;88(4):295-310. doi: 10.1037/ccp0000483.
Irritable bowel syndrome (IBS) is a chronic disorder of brain-gut interaction. Previous studies suggest that mindfulness could be therapeutic for IBS patients, however no study has evaluated the effects of mindfulness-based cognitive therapy adapted for patients with IBS (MBCT-IBS). A 6-week MBCT-IBS course was designed to reduce symptoms and increase quality of life. This study aimed to evaluate the effects of MBCT-IBS and to investigate its therapeutic mechanisms in a randomized controlled trial.
Sixty-seven female patients with IBS were randomized to MBCT-IBS (MG; = 36) or a waitlist (WL; = 31) control condition. Patients completed standardized self-report measures of IBS symptom severity, IBS quality of life, maladaptive illness cognitions (catastrophizing, visceral anxiety sensitivity) and mindfulness at baseline, after 2 treatment sessions, at posttreatment, and at 6-week follow-up. Self-referential processing of illness and health was measured with an implicit association test (IAT).
The MG reported significantly greater reductions in IBS symptoms ( = .003) and improvements in quality of life ( < .001) at follow-up compared with the WL. Changes in visceral anxiety sensitivity and pain catastrophizing at posttreatment and reductions in the IAT-score after 2 sessions combined with increases in nonjudgmental awareness at posttreatment mediated reductions in IBS symptoms.
MBCT-IBS has the potential to reduce IBS symptoms and increase quality of life. MBCT-IBS may exert its effect on IBS symptoms via reducing maladaptive illness cognitions and activating changes in self-processing (reducing biases in self-referent processing of illness and health and increasing nonjudgmental awareness). (PsycINFO Database Record (c) 2020 APA, all rights reserved).
肠易激综合征（IBS）是一种脑-肠相互作用的慢性疾病。先前的研究表明，正念可能对 IBS 患者具有治疗作用，但尚无研究评估针对 IBS 患者的正念认知疗法（MBCT-IBS）的效果。本研究设计了一个为期 6 周的 MBCT-IBS 课程，以减轻症状并提高生活质量。本研究旨在评估 MBCT-IBS 的效果，并在随机对照试验中研究其治疗机制。
67 名女性 IBS 患者被随机分为 MBCT-IBS 组（MG；n = 36）或等待名单组（WL；n = 31）。患者在基线时、2 次治疗后、治疗后和 6 周随访时完成了 IBS 症状严重程度、IBS 生活质量、适应不良的疾病认知（灾难化、内脏焦虑敏感性）和正念的标准化自我报告测量。使用内隐联想测验（IAT）测量疾病和健康的自我参照加工。
与 WL 相比，MG 在随访时报告 IBS 症状明显减轻（ =.003），生活质量显著提高（ <.001）。治疗后，内脏焦虑敏感性和疼痛灾难化的变化以及 2 次治疗后的 IAT 评分降低与治疗后非判断性意识的增加相结合，介导了 IBS 症状的减轻。
MBCT-IBS 有可能减轻 IBS 症状并提高生活质量。MBCT-IBS 可能通过减少适应不良的疾病认知和激活自我加工的变化（减少对疾病和健康的自我参照加工的偏差，增加非判断性意识）来对 IBS 症状产生影响。（PsycINFO 数据库记录（c）2020 APA，保留所有权利）。
