Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yatsen University, 510275 Guangzhou, China.
Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 530022 Nanning, China.
Mini Rev Med Chem. 2020;20(4):286-293. doi: 10.2174/1389557519666191009162641.
Flavonoids are an important class of phytopharmaceuticals in plants. Naringin (naringenin- 7-O-rhamnoglucoside) is a flavanone glycoside isolated from folk herbal medicine Exocarpium Citri grandis (called Huajuhong in Chinese). Massive experimental works have been performed on naringin describing its phytochemical, pharmacokinetic, and bioactive properties. Naringin was found to possess multiple pharmacological activities in relieving inflammation, diabetes, neurodegeneration, cardiovascular disorders, and metabolic syndrome. Recently, it has been approved as a potential antitussive and expectorant for clinical trials. However, the pharmacokinetic aspects of naringin and its therapeutic potentials in respiratory diseases have not been comprehensively reviewed. The present review provides highlights of naringin with respect to its absorption, distribution, metabolism, excretion and its therapeutic effects on cough, phlegm, and pulmonary inflammation. This review would be helpful for the interpretation of pharmacokinetics and pharmacodynamics of naringin in clinical trials.
类黄酮是植物中一类重要的植物药。柚皮苷（柚皮素-7-O-鼠李糖苷）是从民间草药枳实（中文名为化橘红）中分离得到的一种黄酮类糖苷。对柚皮苷的植物化学、药代动力学和生物活性特性进行了大量的实验研究。研究发现，柚皮苷具有多种缓解炎症、糖尿病、神经退行性疾病、心血管疾病和代谢综合征的药理活性。最近，它已被批准作为一种有潜力的镇咳药和祛痰药进行临床试验。然而，柚皮苷的药代动力学及其在呼吸系统疾病中的治疗潜力尚未得到全面综述。本综述重点介绍了柚皮苷的吸收、分布、代谢、排泄及其对咳嗽、咳痰和肺部炎症的治疗作用。这将有助于解释临床试验中柚皮苷的药代动力学和药效学。
