Roark Hunter K, Jenks Jennifer A, Permar Sallie R, Schleiss Mark R
Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Minneapolis, Minnesota, USA.
J Infect Dis. 2020 Mar 5;221(Suppl 1):S60-S73. doi: 10.1093/infdis/jiz484.
Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.
尽管巨细胞病毒（CMV）具有种属特异性，但在动物模型中对非人CMV的研究有助于为开发人类巨细胞病毒（HCMV）疫苗的研究提供信息并加以指导。由于开发HCMV疫苗背后的驱动力是预防先天性感染，因此所讨论的动物模型必须是病毒能够垂直传播给胎儿的模型。幸运的是，两种这样的动物模型——恒河猴CMV和豚鼠CMV——都具有先天性感染的特征。因此，在旨在阻断胎盘传播的孕前疫苗接种的“概念验证”研究中，可以对每个模型进行评估。本综述重点关注各个模型系统的异同，并讨论每个模型与HCMV疫苗研究相关的关键见解。
