非原发性母源性巨细胞病毒感染的围产期结局：15年经验总结
Perinatal Outcomes of Non-Primary Maternal Cytomegalovirus Infection: A 15-Year Experience.
作者信息
Simonazzi Giuliana, Curti Alessandra, Cervi Francesca, Gabrielli Liliana, Contoli Margherita, Capretti Maria Grazia, Rizzo Nicola, Guerra Brunella, Farina Antonio, Lazzarotto Tiziana
机构信息
Division of Obstetrics and Prenatal Medicine, Department of Medical Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
出版信息
Fetal Diagn Ther. 2018;43(2):138-142. doi: 10.1159/000477168. Epub 2017 Jul 12.
OBJECTIVE
To evaluate perinatal outcomes in case of non-primary maternal cytomegalovirus (CMV) infection.
METHODS
We performed a retrospective cohort study of pregnant women with active CMV infection referred to our unit over a 15-year period (January 2000 to December 2014). Non-primary infection was diagnosed on the basis of the results of confirmatory serological and virological tests (avidity test, immunoblotting, real-time PCR-DNA). The vertical transmission rate and the percentage of symptomatic congenital infection were determined in this group of patients.
RESULTS
A total of 205 pregnant women were enrolled. Congenital infection occurred in 7 (3.4%) fetuses/neonates. Symptomatic disease was present at birth in 3 of the 7 congenitally infected neonates (1.5%). Two out of 3 symptomatic newborns presented a pathologic second-trimester ultrasound scan.
CONCLUSION
Maternal immunity offers substantial protection against intrauterine transmission of CMV infection, but not against disease once the fetus is infected.
目的
评估非原发性孕妇巨细胞病毒（CMV）感染的围产期结局。
方法
我们对15年间（2000年1月至2014年12月）转诊至我院的活动性CMV感染孕妇进行了一项回顾性队列研究。根据确证性血清学和病毒学检测结果（亲和力检测、免疫印迹、实时PCR-DNA）诊断非原发性感染。在这组患者中确定垂直传播率和有症状先天性感染的百分比。
结果
共纳入205名孕妇。7例（3.4%）胎儿/新生儿发生先天性感染。7例先天性感染新生儿中有3例（1.5%）出生时患有症状性疾病。3例有症状的新生儿中有2例在孕中期超声检查显示病理改变。
结论
母体免疫可提供对CMV感染宫内传播的实质性保护，但胎儿一旦感染则无法预防疾病。
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