Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
Adv Mater. 2020 Apr;32(16):e2000376. doi: 10.1002/adma.202000376. Epub 2020 Mar 5.
Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)-release device is developed to achieve long-term, long-distance, remote-controllable gas therapy for cancer. The device consists of a wirelessly powered light-emitting diode (wLED) and S-nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO-release wLED (NO-wLED). It is found that NO release from the NO-wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 × 10 m min , which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO-wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO-wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long-wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote-controlled by wireless charging.
传统的光疗面临着一个问题，即光的穿透力不足，很难到达深部病变部位，这大大降低了癌症治疗的可行性。在这里，开发了一种可植入的一氧化氮（NO）释放装置，以实现癌症的长期、远距离、远程可控气体治疗。该装置由一个无线供电的发光二极管（wLED）和用聚二甲基硅氧烷（PDMS）封装的 S-亚硝基谷胱甘肽组成，得到 NO 释放的 wLED（NO-wLED）。研究发现，NO-wLED 中的 NO 释放可以通过无线充电触发，产生的 NO 的浓度达到 0.43×10 m min ，可以对癌细胞产生杀伤作用。体内抗癌实验表明，当植入的 NO-wLED 被无线充电照射时，对原位癌症的生长有明显的抑制作用。此外，手术后由 NO-wLED 产生的 NO 可以防止癌症复发。通过在体内照射，该策略克服了传统光疗穿透力差和长波长依赖性的问题，为无线充电控制的体内气体治疗提供了一种有前途的方法。
