Liang Danna, Kuang Gaizhen, Chen Xiang, Lu Jianhua, Shang Luoran, Sun Weijian
Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang China.
Smart Med. 2023 Jun 14;2(3):e20230016. doi: 10.1002/SMMD.20230016. eCollection 2023 Aug.
Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S-nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near-infrared light (NIR)-responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor-killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR-responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR-responsive NO microcarriers are promising candidates in clinical tumor therapy applications.
一氧化氮（NO）在肿瘤治疗中已显示出巨大潜力，而用于精确可控释放NO的平台开发仍有待探索。在此，提出了一种微流控电喷雾策略，用于制备包封NO供体（S-亚硝基谷胱甘肽，GSNO）以及黑磷（BP）和化疗药物阿霉素（DOX）的水凝胶微球，作为肿瘤治疗的微载体。基于BP的优异光热性能和GSNO的热敏感性，这些微载体呈现出近红外光（NIR）响应性的NO释放行为。此外，微载体的光热性能加速了DOX的释放。所有这些通过结合包括NO治疗、光热治疗和化疗在内的多种治疗策略，促成了微载体优异的肿瘤杀伤效果。此外，已证明近红外响应性NO递送微载体在体内可显著抑制肿瘤生长且无明显副作用。因此，相信新型近红外响应性NO微载体在临床肿瘤治疗应用中是有前景的候选者。
