Peltonen J, Kahri A, Karaharju E, Alitalo I
Invalid Foundation Orthopedic Hospital, Helsinki, Finland.
Acta Orthop Scand. 1988 Dec;59(6):675-80. doi: 10.3109/17453678809149423.
In 18 sheep, gradual physeal distraction of the distal radius was performed by external fixation. Separation of the physis from the metaphysis occurred in all the sheep. Prior to bone formation, collagen fibers were organized according to the direction of the distraction, and lamellar bone was formed if the collagen bundles were lineally organized. In the area where the collagen was disorganized, and also near the periosteum, woven bone was first formed, which was then remodeled into lamellar bone. In some sheep separate groups of chondrocytes were isolated in the metaphyseal area after the distraction. In 2 animals a double physis was formed in the metaphyseal area. This was obviously due to the separation of proliferative chondrocytes in the metaphysis as a result of distraction. After consolidation of the distraction area, this zone of chondrocytes, located in the metaphysis, was still producing new bone 20 weeks postoperatively.
对18只绵羊的桡骨远端进行了逐步的骨骺牵张，采用外固定法。所有绵羊的骨骺与干骺端均发生分离。在骨形成之前，胶原纤维按照牵张方向排列，如果胶原束呈线性排列，则形成板层骨。在胶原排列紊乱的区域以及靠近骨膜的区域，首先形成编织骨，然后再重塑为板层骨。在一些绵羊中，牵张后干骺端区域分离出了几组软骨细胞。在2只动物的干骺端区域形成了双骨骺。这显然是由于牵张导致干骺端增殖性软骨细胞分离所致。牵张区域愈合后，位于干骺端的这组软骨细胞在术后20周仍在产生新骨。
