多发性骨髓瘤患者的根尖周炎患病率。

Prevalence of Apical Periodontitis in patients with Multiple Myeloma.

机构信息

School of Medicine and Dentistry, University of Murcia Hospital Morales Meseguer 2 pl. Av. Marqués de los Vélez, s/n 30008, Murcia, Spain

出版信息

Med Oral Patol Oral Cir Bucal. 2020 May 1;25(3):e383-e387. doi: 10.4317/medoral.23416.

DOI:10.4317/medoral.23416

PMID:32134898

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7211371/

Abstract

BACKGROUND

Aim Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects.

MATERIAL AND METHODS

Methodology Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by 2 two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical index (PAI). Data included systemic health, technical quality of root fillings, total number of teeth, quality of restoration, and periapical status. Statistical evaluation of differences between groups included used chi-squared tests and Fisher's exact tests.

RESULTS

The prevalence of root canal-treated teeth was 10.11% in the MM group and 12.05% in the control group (p=0.90). The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p=0.05). AP in 1 or more teeth was found in 86 % and in 78% of the patients in the MM and the control groups, respectively. When analyzed by subject, there was no statistically significant difference in the prevalence of AP (p>0.72). Similarly there was also no statistically significant difference in the prevalence of PA (p=0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups.

CONCLUSIONS

The presence of AP and endodontic treatment was not significantly different in individuals with MM compared with control subjects. Future studies are needed to elucidate and confirm the association between MM and AP.

摘要

背景

目的先前的报告分析了根尖周病（AP）与全身疾病的患病率/关联。本研究旨在分析多发性骨髓瘤（MM）患者健康/患病根尖和牙髓治疗的患病率，并将结果与对照组进行比较。

材料和方法

方法评估了 50 名 MM 患者的全景片，并与性别和年龄与患病组完全匹配的 50 名对照者进行了比较。在标准化条件下，由 2 名经验丰富的牙髓病专家进行放射学分析。使用根尖指数（PAI）评估根尖状态（存在或不存在 AP）。数据包括系统健康状况、根管充填技术质量、牙齿总数、修复质量和根尖状态。使用卡方检验和 Fisher 确切检验对组间差异进行统计学评估。

结果

MM 组根管治疗牙的患病率为 10.11%，对照组为 12.05%（p=0.90）。实验组的平均根管治疗牙数为 2 个，对照组为 2.48 个，差异具有统计学意义（p=0.05）。1 颗或多颗牙齿发生 AP 的患者分别占 MM 组和对照组的 86%和 78%。按个体分析时，AP 的患病率无统计学差异（p>0.72）。同样，按牙分析时，AP 在 MM 组和对照组中的患病率也无统计学差异（p=0.85），分别为 63.2%和 62.9%。