Faculty of Dentistry Tabriz University of Medical Sciences Tabriz, IR Iran
Med Oral Patol Oral Cir Bucal. 2020 May 1;25(3):e410-e415. doi: 10.4317/medoral.23460.
Oral lichen planus (OLP) is a premalignant mucocutaneous disease that affects 1-2% of the adult population. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are important in pathogenesis of OLP. Interleukin-4 (IL-4) is secreted by T-helper 2 (Th2). Several studies have been carried out on the role of IL-4 in OLP. The aim of this study was to review the level of IL-4 in OLP, effective factors in the production of IL-4 and its role in the development of OLP.
A search in PubMed was performed on the literature published from 2000 until august 2019 using the following keywords: "oral lichen planus" or "OLP" and "interleukin-4" or "IL-4".
Originally, 37 articles were considered, of which 28 case-control articles were selected according to the inclusion/exclusion criteria.
This review study shows that IL-4 plays a key role in the development of OLP. According to the past studies, there are several factors contributing to the production of this cytokine. Identification of the routes of production of IL-4 and its role in OLP might be useful for development of new preventive and therapeutic methods in management of patients with OLP.
口腔扁平苔藓（OLP）是一种影响 1-2%成年人的癌前黏膜疾病。免疫因素可能是其病因。T 细胞等细胞免疫细胞在 OLP 的发病机制中起重要作用。白细胞介素-4（IL-4）由辅助性 T 细胞 2（Th2）分泌。已经进行了几项关于 IL-4 在 OLP 中的作用的研究。本研究旨在综述 OLP 中 IL-4 的水平、IL-4 产生的影响因素及其在 OLP 发病机制中的作用。
在 PubMed 上搜索了从 2000 年到 2019 年 8 月发表的文献，使用的关键词是：“口腔扁平苔藓”或“OLP”和“白细胞介素-4”或“IL-4”。
最初考虑了 37 篇文章，根据纳入/排除标准选择了 28 篇病例对照文章。
本综述研究表明，IL-4 在 OLP 的发展中起关键作用。根据过去的研究，有几个因素有助于这种细胞因子的产生。鉴定 IL-4 的产生途径及其在 OLP 中的作用可能有助于开发新的预防和治疗方法来管理 OLP 患者。
