Ma Hui, Wu Yuanqin, Yang Huamei, Liu Jiajia, Dan Hongxia, Zeng Xin, Zhou Yu, Jiang Lu, Chen Qianming
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Aug;122(2):164-73. doi: 10.1016/j.oooo.2016.03.018. Epub 2016 Mar 31.
Oral lichen planus (OLP) is a potentially premalignant condition with unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, can act as critical players in the immunopathogenesis of OLP. MicroRNAs (miRNAs) are closely correlated with cytokines in various inflammation-related diseases. In patients with OLP, miRNA-146a and miRNA-155 are increased in peripheral blood mononuclear cells, and numerous miRNAs have been shown to exhibit altered expression profiles in lesions. Although the microRNA-messenger RNA (miRNA-mRNA) network is thought to be involved in the development of OLP, in-depth studies are lacking. Here, we summarize current data on the mechanisms of action of miRNAs regulating typical cytokines in OLP, including interleukin (IL)-10, IL-17, IL-22, IFN-γ, and TNF-α, to study the genetic basis of the pathogenesis of OLP and to provide prospects of therapy.
口腔扁平苔藓（OLP）是一种发病机制不明的潜在癌前病变。免疫和炎症因素被认为在OLP的发生发展中起重要作用，细胞因子，如干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α，可在OLP的免疫发病机制中发挥关键作用。微小RNA（miRNA）与各种炎症相关疾病中的细胞因子密切相关。在OLP患者中，外周血单个核细胞中的miRNA-146a和miRNA-155增加，并且已显示许多miRNA在病变中表现出表达谱改变。尽管微小RNA-信使核糖核酸（miRNA-mRNA）网络被认为参与了OLP的发生发展，但仍缺乏深入研究。在此，我们总结了目前关于miRNA调节OLP中典型细胞因子（包括白细胞介素（IL）-10、IL-17、IL-22、IFN-γ和TNF-α）作用机制的数据，以研究OLP发病机制的遗传基础并提供治疗前景。
